Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 9, Number 10—October 2003
Dispatch

Wild-type Measles Virus in Brain Tissue of Children with Subacute Sclerosing Panencephalitis, Argentina

Paola Roxana Barrero*, Jorge Grippo*, Mariana Viegas*, and Alicia Susana Mistchenko*Comments to Author 
Author affiliations: *Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina

Main Article

Figure 2

Phylogenetic relationships of subacute sclerosing panencephalitis (SSPE) strains. The neighbor-joining unrooted tree was plotted with Treeview 1.5.2. Reference measles virus strains are described (2). Wild-type (genotype C1 in 1991 and D6 in 1998) as well as post-vaccinal cases (genotype A) from the last two Argentine outbreaks were included (GenBank accession no. AF263841, 43, 44, 46, 52) (7). SSPE strains are highlighted in bold type (GenBank accession no. AY253332–37)

Figure 2. Phylogenetic relationships of subacute sclerosing panencephalitis (SSPE) strains. The neighbor-joining unrooted tree was plotted with Treeview 1.5.2. Reference measles virus strains are described (2). Wild-type (genotype C1 in 1991 and D6 in 1998) as well as post-vaccinal cases (genotype A) from the last two Argentine outbreaks were included (GenBank accession no. AF263841, 43, 44, 46, 52) (7). SSPE strains are highlighted in bold type (GenBank accession no. AY253332–37)

Main Article

References
  1. Cutts  FT, Henao-Restrepo  A, Olive  JM, Cutts  FT, Henao-Restrepo  A, Olive  JM. Measles elimination: progress and challenges. Vaccine. 1999;17(Suppl 3):S47–52. DOIPubMedGoogle Scholar
  2. Hersh  BS, Tambini  G, Nogueira  AC, Carrasco  P, de Quadros  C. Review of regional measles surveillance data in the Americas, 1996–99. Lancet. 2000;355:1943–8. DOIPubMedGoogle Scholar
  3. Norrby  E, Kristensson  K. Measles virus in the brain. Brain Res Bull. 1997;44:213–20. DOIPubMedGoogle Scholar
  4. World Health Organization. Nomenclature for describing the genetic characteristics of wild-type measles viruses (update). Part I. Wkly Epidemiol Rec. 2001;76:242–7.PubMedGoogle Scholar
  5. Cattaneo  R, Schmid  A, Spielhofer  P, Kaelin  K, Baczko  K, ter Meulen  V, Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology. 1989;173:415–25. DOIPubMedGoogle Scholar
  6. Baczko  K, Liebert  UG, Billeter  M, Cattaneo  R, Budka  H, ter Meulen  V. Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis. J Virol. 1986;59:472–8.PubMedGoogle Scholar
  7. Rima  BK, Earle  AP, Baczko  K, ter Meulen  V, Liebert  UG, Carstens, et al. Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture. J Gen Virol. 1997;78:97–106.PubMedGoogle Scholar
  8. Gark  RK. Subacute sclerosing panencephalitis. Postgrad Med J. 2002;78:63–70. DOIPubMedGoogle Scholar
  9. Barrero  PR, Zandomeni  RO, Mistchenko  AS. Measles virus circulation in Argentina: 1991–1999. Arch Virol. 2001;146:815–23. DOIPubMedGoogle Scholar
  10. Thompson  JD, Gibson  TJ, Plewniak  F, Jeanmougin  F, Higgins  DG. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 1997;24:4876–82. DOIGoogle Scholar
  11. Felsestein  J. PHYLIP- Phylogeny inference package. Cladistics. 1989;5:164–6.
  12. Bilkis  MD, Barrero  PR, Mistchenko  AS. Measles resurgence in Argentina: 1997–98 outbreak. Epidemiol Infect. 2000;124:289–93. DOIPubMedGoogle Scholar
  13. Backzo  K, Lampe  J, Liebert  UG, Brinckmann  U, ter Meulen  V, Pardowitz  I, Clonal expansion of hypermutated measles virus in a SSPE brain. Virology. 1993;197:188–95. DOIPubMedGoogle Scholar
  14. Liebert  UG, Flanagan  SG, Löffler  S. Antigenic determinants of measles virus hemagglutinin associated with neurovirulence. J Virol. 1994;68:1486–93.PubMedGoogle Scholar
  15. Ziegler  D, Fournier  P, Berbers  GAH, Steuer  H, Wiesmüller  KH, Fleckenstein  B, Protection against measles virus encephalitis by monoclonal antibodies binding to a cysteine loop domain of the H protein mimicked by peptides which are not recognised by maternal antibodies. J Gen Virol. 1996;77:2479–89. DOIPubMedGoogle Scholar
  16. Buckland  R, Giraldon  P, Wild  TF. Expression of measles virus nucleoprotein in Escherichia coli: use of deletion mutants to locate the antigenic sites. J Gen Virol. 1989;70:435–41. DOIPubMedGoogle Scholar
  17. Oliveira  MI, Rota  PA, Suely  PC, Figueiredo  CA, Afonso  AMS, Theobaldo  M, Genetic homogeneity of measles viruses associated with a measles outbreak, São Paulo, Brazil, 1997. Emerg Infect Dis. 2002;8:808–13.PubMedGoogle Scholar
  18. Jin  L, Beard  S, Hunjan  R, Brown  DW, Miller  E. Characterization of measles virus strains causing SSPE: a study of 11 cases. J Neurovirol. 2002;8:335–44. DOIPubMedGoogle Scholar
  19. Miki  K, Komase  K, Mgone  CS, Kawanishi  R, Iijima  M, Mgone  JM, Molecular analysis of measles virus genome derived from SSPE and acute measles patients in Papua, New Guinea. J Med Virol. 2002;68:105–12. DOIPubMedGoogle Scholar
  20. Lawrence  DMP, Vaughn  MM, Belman  AR, Cole  JS, Rall  GF. Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. J Virol. 1999;73:1795–801.PubMedGoogle Scholar

Main Article

Page created: January 10, 2011
Page updated: January 10, 2011
Page reviewed: January 10, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external