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Volume 9, Number 11—November 2003
Dispatch

Levofloxacin Treatment Failure in Haemophilus influenzae Pneumonia

Teresa Bastida*, María Pérez-Vázquez†, José Campos†, María Cristina Cortés-Lletget‡, Federico Román†, Fe Tubau§, Adela G. de la Campa†, and Carles Alonso-Tarrés‡Comments to Author 
Author affiliations: *Hospital de l´Esperit Sant, Santa Coloma de Gramenet, Barcelona, Spain; †Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain; ‡Hospital de l’Hospitalet, Consorci Sanitari Integral, L’Hospitalet de Llobregat, Barcelona, Spain; §Hospital “Prínceps d’Espanya” Ciutat Sanitària i Universitària de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain

Main Article

Table

Fluoroquinolone susceptibility and amino acid changes in GyrA, ParC, GyrB, and ParE QRDR fragments of three Haemophilus influenzae strains compared with a fully fluoroquinolone-susceptible straina

Strain no. MIC (µg/mL)
 Amino acid at specified positions
CIP LEV MOXI GATI GyrA ParC ParE
ATCC 51907 0.007 0.03 0.01 0.003 84 Ser 88 Asp 84
Ser 420
Asp
32602, 35102, 35202 16 16 8 16 Leu Asn Ile Asn

aQRDR, quinolone resistance-determining regions; CIP, ciprofloxacin; LEV, levofloxacin; MOXI, moxifloxacin; GATI, gatifloxacin. Microdilution used for susceptibility testing (8).

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