Volume 9, Number 12—December 2003
Dispatch
Noninvasive Method for Monitoring Pneumocystis carinii Pneumonia
Table 2
Comparisons of Pneumocystis carinii–specific DNA levels in pre- and postimmunosuppression samples, lung homogenates, and organism numbers in lung homogenates assessed by microscopic enumerationa
Groupsb | No. points | Spearman r | 95% Confidence interval | p value | Significant |
---|---|---|---|---|---|
LH Pc DNA vs. post-OS Pc DNA |
22 |
0.5576 |
0.1648 to 0.7978 |
0.0070 |
Yes |
LH Pc DNA vs. Pc nuclei |
22 |
0.9035 |
0.7731 to 0.9606 |
<0.0001 |
Yes |
Post-OS Pc DNA vs. Pc Nuclei |
22 |
0.4636 |
0.0388 to 0.7465 |
0.0298 |
Yes |
Pre-OS Pc DNA vs. post-OS Pc DNA |
21* |
0.3707 |
-0.0863 to 0.6988 |
0.0980 |
No |
Pre-OS Pc DNA vs Pc Nuclei |
21 |
0.4123 |
-0.0374 to 0.7232 |
0.0633 |
No |
Pre-OS Pc DNA vs. LH Pc DNA | 21 | 0.2939 | -0.1712 to 0.6519 | 0.1960 | No |
a21 data points were included in these analyses because 2 rats from the 10-wk group died and 1 preimmunosuppression oral swab sample in the 7-wk group was lost in processing.
bPre-OS Pc DNA, P. carinii –specific DNA from oral swabs taken prior to immunosuppression; post-OS Pc DNA, P. carinii–specific DNA from oral swabs taken at the time of euthanasia; LH Pc DNA, P. carinii–specific DNA from lung homogenates of rats at the 3 different time points; log Pc Nuclei, P. carinii organism number assessed by microscopic enumeration.