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Volume 9, Number 4—April 2003


Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model

L. Temime*Comments to Author , P.Y. Boëlle*, P. Courvalin†, and D. Guillemot†
Author affiliations: *Institute National de la Santé et de la Recherdhé, Paris, France; †Unité des Agents Antibactériens, Institut Pasteur, Paris, France

Main Article

Table 1

Model parameters and their values (8,21)

Parameters (at MIC m) Pneumococci Meningococci
Treatment duration 1/γ 8 d 8 d
Weighted frequency of treatment α 1 / 2 y 1 / 3 y
Refractory phase duration 1/θ 2 wk 2 wk
Carriage duration 1/λ 2.2 mo 10 mo
Time before antibiotic action 1/ν 4 d 4 d
Contact rate (absence of treatment) β 0.23 wk-1person-1 0.026 wk-1person-1
Contact rate (presence of treatment) β´(m) formula image formula image
Nondecolonization probability after treatment σ (m) formula image formula image
MIC increase after a genetic event F (m) Randomly selected from a seminormal law

Main Article