Volume 9, Number 6—June 2003
Research
Molecular Subtyping To Detect Human Listeriosis Clusters
Brian D. Sauders*†, Esther D. Fortes†, Dale L. Morse*‡, Nellie Dumas*, Julia A. Kiehlbauch*, Ynte Schukken†, Jonathan R. Hibbs*, and Martin Wiedmann†
Table 2
Comparison of statistically significant temporal listeriosis clusters stratified by subtyping technique used to detect and confirm each cluster
| Clusters | Cluster definition | No. of clusters | No. of cases (%)a |
|---|---|---|---|
| 1. Clusters detected by ribotype or PFGE | Ribotype clusters or PFGE clusters detected by using the scan statistic (p<0.05) | 9 | 41 (31) |
| 2. Ribotype clusters | Indistinguishable ribotype pattern clusters detected by the scan statistic (p<0.05) | 6 | 31 (24) |
| 2a. Ribotype clusters supported by PFGE | Ribotype clusters, containing closely related PFGE types (<3 bands difference) | 6 | 26 (20) |
| 3. PFGE clusters | Indistinguishable PFGE patterns detected by the scan statistic (p<0.05) | 8 | 31 (24) |
| 3a. PFGE clusters supported by ribotype | PFGE clusters, which contained identical ribotype patterns | 8 | 30 (23) |
| 4. Clusters supported by ribotype and PFGE | Clusters detected as 2a and 3a | 5 | 23 (18) |
| 5. Epidemiologically linked ribotype or PFGE clusters | Clusters detected by ribotype, PFGE, or both and supported by epidemiologic data | 2 | 17 (13) |
aBased on total sample population of 131 isolates; PFGE, pulsed-field gel electrophoresis.
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