Volume 9, Number 7—July 2003
Antimicrobial Susceptibility Breakpoints and First-Step parC Mutations in Streptococcus pneumoniae: Redefining Fluoroquinolone Resistance
|ParC amino acid substitution||No. isolates inhibited by levofloxacin MIC (µg/mL) of
||Total no. of strains|
|No. isolates/total with amino acid substitutions||48/82 (59%)||5/8a (63%)||10/10||11/11||4/4||78/115 (69%)|
aOne isolate with no ParC amino acid substitution found to have active efflux; two isolates had ParC amino acid substitutions at sites other than Ser79 or Asp83.
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