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Volume 9, Number 7—July 2003


Antimicrobial Susceptibility Breakpoints and First-Step parC Mutations in Streptococcus pneumoniae: Redefining Fluoroquinolone Resistance

Sue Lim*†, Darrin Bast*†, Allison McGeer*†, Joyce de Azavedo*†, and Donald E. Low*†Comments to Author 
Author affiliations: *Toronto Medical Laboratories/Mount Sinai Hospital, Toronto, Ontario, Canada; †University of Toronto, Toronto, Ontario, Canada

Main Article

Table 2

Number of isolates with ParC and GyrA amino acid substitutions and their corresponding levofloxacin MICs

MIC (μg/mL) No. strains with amino acid substitutions in
ParC (%) ParC and GyrA (%)
2 48/82 (59) 0/29a (0)
4 5/8 (63) 3/8 (38)
8 0/10 (0) 10/10 (100)
≥16 0/15 (0) 15/15 (100)

a29/82 isolates were randomly examined for GyrA mutations.

Main Article