Volume 10, Number 3—March 2004
Dispatch
Endemic Carbapenem-resistant Pseudomonas aeruginosa with Acquired Metallo-β-lactamase Determinants in European Hospital
Cristina Lagatolla*
, Enrico A. Tonin*, Carlo Monti-Bragadin*, Lucilla Dolzani*, Francesca Gombac*, Claudia Bearzi*, Elisabetta Edalucci*, Fabrizia Gionechetti*, and Gian Maria Rossolini†
, Enrico A. Tonin*, Carlo Monti-Bragadin*, Lucilla Dolzani*, Francesca Gombac*, Claudia Bearzi*, Elisabetta Edalucci*, Fabrizia Gionechetti*, and Gian Maria Rossolini†
Table 2
Antimicrobial susceptibility of the 89 imipenem-resistant Pseudomonas aeruginosa isolatesa
| Drug resistance profileb | blaVIM status |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| blaVIM-1 (n = 54) (%) | blaVIM-2 (n = 10) (%) | blaVIM-negative (n = 25) (%) | ||||||||||
| Imi |
Mem |
Caz |
Pip |
Atm |
Ak |
Gm |
Tob |
Cip |
39 (72) |
10 (100) |
7 (28) |
|
| Imi |
Mem |
Caz |
Pip |
Atm |
Gm |
Tob |
Cip |
11 (20) |
- |
6 (24) |
||
| Imi |
Mem |
Caz |
Pip |
Gm |
Tob |
Cip |
1 (2) |
- |
1 (4) |
|||
| Imi |
Mem |
Caz |
Pip |
Ak |
Gm |
Tob |
Cip |
2 (4) |
- |
- |
||
| Imi |
Mem |
Caz |
Ak |
Gm |
Tob |
Cip |
1 (2) |
- |
- |
|||
| Otherc | - | - | 11 (44) | |||||||||
aAll isolates were susceptible to polymixin B. The percentage of isolates resistant to all the tested drugs (except polymixin B) was significantly higher among blaVIM-positive isolates (76 vs. 28%; p < 0.001, according to the χ2 test).
bImi, imipenem; Mem, meropenem; Caz, ceftazidime; Pip, piperacillin; Atm, aztreonam; Ak, amikacin; Gm, gentamicin; Tob, tobramycin; Cip, ciprofloxacin.
cStrains resistant to fewer than 5 antibiotics.
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