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Volume 13, Number 2—February 2007
Synopsis

Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections

Janie Parrino*, Richard S. Hotchkiss†, and Mike Bray*Comments to Author 
Author affiliations: *National Institutes of Health, Bethesda, Maryland, USA; †Washington University School of Medicine, Saint Louis, Missouri, USA;

Main Article

Figure 3

Decreased apoptosis caused by overexpression of Bcl-2 protein in a mouse model of plague. Wild-type mice (A) and mice that overexpressed Bcl-2 in lymphocytes (B) were injected intranasally with Yersinia pestis. Thymuses were obtained at 72 h postinfection and stained by using the terminal deoxynucleotidyl method as a marker of apoptotic cell death. Note the decrease in apoptotic cells in the thymus of the Bcl-2 transgenic mouse (magnification ×400).

Figure 3. Decreased apoptosis caused by overexpression of Bcl-2 protein in a mouse model of plague. Wild-type mice (A) and mice that overexpressed Bcl-2 in lymphocytes (B) were injected intranasally with Yersinia pestis. Thymuses were obtained at 72 h postinfection and stained by using the terminal deoxynucleotidyl method as a marker of apoptotic cell death. Note the decrease in apoptotic cells in the thymus of the Bcl-2 transgenic mouse (magnification ×400).

Main Article

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Page updated: June 29, 2010
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