Volume 13, Number 2—February 2007
Research
Meningococcal Disease in South Africa, 1999–2002
Garry B. Coulson*, Meningeal Disease Surveillance in South Africa
, Mignon du Plessis*, Anthony M. Smith*, Linda de Gouveia*, Keith P. Klugman*†, Anne von Gottberg* , and for the Group for EntericRespiratoryGERMS-SA
, Mignon du Plessis*, Anthony M. Smith*, Linda de Gouveia*, Keith P. Klugman*†, Anne von Gottberg* , and for the Group for EntericRespiratoryGERMS-SA
Table 2
Genotypic data of Neisseria meningitidis isolates causing invasive disease as reported in South Africa, August 1999 through July 2002*
| Serogroup | PFGE clusters | No. of isolates | MLST results | |||||
|---|---|---|---|---|---|---|---|---|
| 1999/2000, n | 2000/2001, n | 2001/2002, n | Total, N (%) | ST | ST complex | n | ||
| A | Total | 13 | 38 | 72 | 123 | |||
| Cluster A-1 | 5 | 34 | 70 | 109 (89) | 1 | ST-1/subgroup I/II | 12 | |
| Small clusters/single isolates | 8 | 4 | 2 | 14 (11) | 7 | ST-5/subgroup III complex | 2 | |
| 254 | ST-254 complex | 1 | ||||||
| 175 | None | 1 | ||||||
| B | Total | 107 | 77 | 58 | 242 | |||
| Cluster B-1 | 38 | 28 | 25 | 91 (38) | 33 | ST-32/ET-5 complex | 4 | |
| 4239 | ST-32/ET-5 complex | 1 | ||||||
| Cluster B-2 | 12 | 7 | 10 | 29 (12) | 154 | ST-41/44/lineage III | 2 | |
| 4242 | ST-41/44/lineage III | 1 | ||||||
| Cluster B-3 | 11 | 9 | 3 | 23 (9.5) | ||||
| Cluster B-4 | 7 | 4 | 6 | 17 (7) | 35 | ST-35 complex | 1 | |
| Cluster B-5 | 3 | 6 | 5 | 14 (6) | ||||
| Small clusters/single isolates | 36 | 23 | 9 | 68 (28) | ||||
| C | Total | 20 | 12 | 17 | 49 | |||
| Cluster C-1 | 5 | 5 | 5 | 15 (31) | 11 | ST-11/ET-37 complex | 2 | |
| Cluster C-2 | 3 | 2 | 4 | 9 (18) | 865 | None | 2 | |
| Cluster C-3 | 4 | 1 | 4 | 9 (18) | 33 | ST-32/ET-5 complex | 2 | |
| Small clusters/single isolates | 8 | 4 | 4 | 16 (33) | ||||
| W135 | Total | 9 | 9 | 13 | 31 | |||
| Cluster W-1 | 5 | 7 | 10 | 23 (74) | 11 | ST-11/ET-37 complex | 4 | |
| Cluster W-2 | 2 | 1 | 0 | 3 (10) | 4241 | ST-4241/ST-22 complex | 1 | |
| Small clusters/single isolates | 2 | 1 | 3 | 5 (16) | ||||
| Y | Total | 40 | 38 | 50 | 128 | |||
| Cluster Y-1 | 28 | 25 | 39 | 92 (72) | 175 | None | 6 | |
| Cluster Y-2 | 5 | 8 | 6 | 19 (15) | 23 | ST-23 complex/cluster A3 | 2 | |
| 4245 | ST-23 complex/cluster A3 | 1 | ||||||
| Small clusters/single isolates | 7 | 5 | 5 | 17 (13) | 175 | None | 1 | |
*PFGE, pulsed-field gel electrophoresis; MLST, multilocus sequence typing; ST, sequence type.
1GERMS-SA: Sandeep Vasaikar (Eastern Cape); Nolan Janse van Rensberg, Peter Smith (Free State); Khatija Ahmed, Heather Crewe-Brown, Mike Dove, Charles Feldman, Alan Karstaedt, Olga Perovic, Pyu-Pyu Sein, Ruth Lekalakala (Gauteng); Wim Sturm (KwaZulu Natal); Ken Hamese (Limpopo); Keith Bauer (Mpumalanga); Denise Roditi, Rena Hoffmann, Lynne Liebowitz, John Simpson, Andrew Whitelaw (Western Cape); Adrian Brink (AMPATH); Claire Heney (Lancet); Martinus Senekal (PathCare).
Page created: June 29, 2010
Page updated: June 29, 2010
Page reviewed: June 29, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
Content Credential