Volume 13, Number 2—February 2007
Research
Meningococcal Disease in South Africa, 1999–2002
Table 2
Genotypic data of Neisseria meningitidis isolates causing invasive disease as reported in South Africa, August 1999 through July 2002*
Serogroup | PFGE clusters | No. of isolates | MLST results | |||||
---|---|---|---|---|---|---|---|---|
1999/2000, n | 2000/2001, n | 2001/2002, n | Total, N (%) | ST | ST complex | n | ||
A | Total | 13 | 38 | 72 | 123 | |||
Cluster A-1 | 5 | 34 | 70 | 109 (89) | 1 | ST-1/subgroup I/II | 12 | |
Small clusters/single isolates | 8 | 4 | 2 | 14 (11) | 7 | ST-5/subgroup III complex | 2 | |
254 | ST-254 complex | 1 | ||||||
175 | None | 1 | ||||||
B | Total | 107 | 77 | 58 | 242 | |||
Cluster B-1 | 38 | 28 | 25 | 91 (38) | 33 | ST-32/ET-5 complex | 4 | |
4239 | ST-32/ET-5 complex | 1 | ||||||
Cluster B-2 | 12 | 7 | 10 | 29 (12) | 154 | ST-41/44/lineage III | 2 | |
4242 | ST-41/44/lineage III | 1 | ||||||
Cluster B-3 | 11 | 9 | 3 | 23 (9.5) | ||||
Cluster B-4 | 7 | 4 | 6 | 17 (7) | 35 | ST-35 complex | 1 | |
Cluster B-5 | 3 | 6 | 5 | 14 (6) | ||||
Small clusters/single isolates | 36 | 23 | 9 | 68 (28) | ||||
C | Total | 20 | 12 | 17 | 49 | |||
Cluster C-1 | 5 | 5 | 5 | 15 (31) | 11 | ST-11/ET-37 complex | 2 | |
Cluster C-2 | 3 | 2 | 4 | 9 (18) | 865 | None | 2 | |
Cluster C-3 | 4 | 1 | 4 | 9 (18) | 33 | ST-32/ET-5 complex | 2 | |
Small clusters/single isolates | 8 | 4 | 4 | 16 (33) | ||||
W135 | Total | 9 | 9 | 13 | 31 | |||
Cluster W-1 | 5 | 7 | 10 | 23 (74) | 11 | ST-11/ET-37 complex | 4 | |
Cluster W-2 | 2 | 1 | 0 | 3 (10) | 4241 | ST-4241/ST-22 complex | 1 | |
Small clusters/single isolates | 2 | 1 | 3 | 5 (16) | ||||
Y | Total | 40 | 38 | 50 | 128 | |||
Cluster Y-1 | 28 | 25 | 39 | 92 (72) | 175 | None | 6 | |
Cluster Y-2 | 5 | 8 | 6 | 19 (15) | 23 | ST-23 complex/cluster A3 | 2 | |
4245 | ST-23 complex/cluster A3 | 1 | ||||||
Small clusters/single isolates | 7 | 5 | 5 | 17 (13) | 175 | None | 1 |
*PFGE, pulsed-field gel electrophoresis; MLST, multilocus sequence typing; ST, sequence type.
1GERMS-SA: Sandeep Vasaikar (Eastern Cape); Nolan Janse van Rensberg, Peter Smith (Free State); Khatija Ahmed, Heather Crewe-Brown, Mike Dove, Charles Feldman, Alan Karstaedt, Olga Perovic, Pyu-Pyu Sein, Ruth Lekalakala (Gauteng); Wim Sturm (KwaZulu Natal); Ken Hamese (Limpopo); Keith Bauer (Mpumalanga); Denise Roditi, Rena Hoffmann, Lynne Liebowitz, John Simpson, Andrew Whitelaw (Western Cape); Adrian Brink (AMPATH); Claire Heney (Lancet); Martinus Senekal (PathCare).
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