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Volume 13, Number 5—May 2007

Dispatch

Chikungunya Virus in US Travelers Returning from India, 2006

Robert S. Lanciotti*Comments to Author , Olga L. Kosoy*, Janeen J. Laven*, Amanda J. Panella*, Jason O. Velez*, Amy J. Lambert*, and Grant L. Campbell*

Author affiliation: *Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Main Article

Table 1

Diagnostic test results for 35 travelers infected with chikungunya virus (CHIKV), 2006*

Sample IgM ELISA† IgG ELISA† PRNT‡ Virus isolation
(Vero cells) RT-PCR§ Viremia, PFU/mL¶ Days from onset of illness
to collection State of US
residence Return date, 2006
1
 17.7
 3.2
 640
 –
 –
 NA
 0
 NJ
 10/12
2
 1.7
 1.7
 <10
 –
 +
 104.0
 1
 CA
 Before 11/28
3
 1.2
 1.1
 ND
 +
 +
 104.1
 1
 IL
 9/29
4
 1.8
 NS
 ND
 +
 +
 106.8
 2
 CA
 Before 9/16
5
 1.2
 0.76
 ND
 +
 +
 105.1
 2
 MA
 9/10
6
 1.8
 1.6
 <10
 +
 +
 106.0
 3
 PA
 Before 8/20
7
 1.6
 1.2
 ND
 +
 +
 105.3
 3
 CA
 10/2
8
 NS
 1.4
 ND
 –
 +
 103.9
 4
 WI
 10/9
9
 22.0
 4.3
 5,120
 –
 –
 NA
 4
 CA
 Before 10/6
10
 1.1
 0.95
 <10
 –
 +
 104.5
 6
 CA
 Before 8/13
11
 7.4
 0.96
 40
 –
 –
 NA
 7
 CA
 Before 9/23
12
 15.0
 0.60
 320
 –
 –
 NA
 8
 CT
 Before 7/6
13
 26.2
 1.2
 160
 ND
 –
 NA
 8
 DC
 Before 10/16
14
 12.9
 5.8
 1,80
 ND
 –
 NA
 10
 CA
 Before 9/22
15
 38.8
 2.3
 2,560
 ND
 ND
 NA
 19
 CT
 Before 7/6
16
 12.7
 1.5
 640
 ND
 –
 NA
 20
 IL
 8/23
17
 16.9
 4.8
 640
 ND
 –
 NA
 30
 IL
 6/25
18
 8.3
 3.7
 640
 ND
 ND
 NA
 31
 HI
 Before 8/2
19
 6.6
 1.5
 640
 ND
 –
 NA
 31
 CA
 Before 8/13
20
 2.6
 6.8
 320
 ND
 –
 NA
 34
 MD
 Before 3/20
21
 5.0
 NS
 640
 ND
 –
 NA
 34
 IL
 Before 9/22
22
 15.1
 4.1
 1,280
 ND
 –
 NA
 38
 CA
 Before 10/2
23
 4.3
 5.9
 2,560
 ND
 –
 NA
 42
 PA
 Before 8/20
24
 5.6
 NS
 320
 ND
 –
 NA
 43
 Unknown
 Unknown
25
 3.1
 3.7
 640
 ND
 –
 NA
 44
 IL
 Before 9/12
26
 26.6
 13.4
 5,120
 ND
 ND
 NA
 48
 SC
 6/24
27
 30.7
 6.6
 5,120
 ND
 –
 NA
 61
 CA
 Before 10/26
28
 6.1
 11.4
 2,560
 ND
 –
 NA
 62
 CT
 Before 10/3
29
 9.4
 16.0
 640
 ND
 –
 NA
 63
 CA
 8/23
30
 7.5
 8.4
 1,280
 ND
 –
 NA
 71
 MN
 6/8
31
 5.3
 5.8
 640
 ND
 –
 NA
 71
 MN
 6/8
32
 3.7
 16.1
 320
 ND
 –
 NA
 75
 LA
 Before 3/30
33
 9.8
 10.1
 2,560
 ND
 –
 NA
 92
 IL
 7/9
34
 7.5
 3.1
 160
 ND
 –
 NA
 101
 PA
 Before 10/13
35 24.6 11.9 20,480 ND – NA Unknown IL Before 11/08

*IgM, immunoglobulin M; PRNT, plaque reduction neutralization test; RT-PCR, reverse transcription–PCR; NA, not applicable; ND, not done
(sampled depleted); NS, nonspecific reaction in ELISA.
†Values are patient sample optical densities divided by a negative control optical density; values >3 are positive.
‡Values are 90% plaque reduction neutralization titers.
§Real-time, fluorescence-based assay for detecting CHIKV RNA; positive samples had crossing threshold values <37 with both primer sets.
¶Estimated CHIKV PFU/mL by real-time RT-PCR using a standard curve generated with plaque-titrated/calibrated CHIKV standards.

Main Article

Page created: June 24, 2010
Page updated: June 24, 2010
Page reviewed: June 24, 2010
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