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Volume 14, Number 1—January 2008
Research

Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza

Cristiana Gioia*, Concetta Castilletti*, Massimo Tempestilli*, Paola Piacentini*, Licia Bordi*, Roberta Chiappini*, Chiara Agrati*, Salvatore Squarcione*, Giuseppe Ippolito*, Vincenzo Puro*, Maria Rosaria Capobianchi*Comments to Author , and Fabrizio Poccia*
Author affiliations: *National Institute for Infectious Diseases “Lazzaro Spallanzani,” Rome, Italy;

Main Article

Appendix Figure

Antigen-specific CD4 T cells against vaccine preparation and influenza virus (H5N1) before (t0) and after (t1) seasonal influenza vaccination. The frequency of CD4 T cells producing interferon-gamma (IFN-?) after stimulation with seasonal vaccine preparation (A), inactivated avian influenza (H5N1) (B), and H5/N1 peptides (C) were analyzed in healthy donors enrolled in the study at baseline (t0) and 1 month after seasonal influenza vaccination (t1). At baseline (white bars), all donors had a detectable level of human influenza–specific CD4 T cells; influenza (H5N1)–specific CD4 response was detectable in 41.6% of study participants. At t1 (black bars), some donors (indicated by *) showed an increase of the frequency of antigen-specific CD4 T cells that were twice as high as those in the pre-vaccination level. This increase was arbitrary but considered significant.

Appendix Figure. Antigen-specific CD4 T cells against vaccine preparation and influenza virus (H5N1) before (t0) and after (t1) seasonal influenza vaccination. The frequency of CD4 T cells producing interferon-gamma (IFN-?) after stimulation with seasonal vaccine preparation (A), inactivated avian influenza (H5N1) (B), and H5/N1 peptides (C) were analyzed in healthy donors enrolled in the study at baseline (t0) and 1 month after seasonal influenza vaccination (t1). At baseline (white bars), all donors had a detectable level of human influenza–specific CD4 T cells; influenza (H5N1)–specific CD4 response was detectable in 41.6% of study participants. At t1 (black bars), some donors (indicated by *) showed an increase of the frequency of antigen-specific CD4 T cells that were twice as high as those in the pre-vaccination level. This increase was arbitrary but considered significant.

Main Article

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