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Volume 14, Number 11—November 2008

Dispatch

Novel Human Rhinoviruses and Exacerbation of Asthma in Children1

Nino Khetsuriani, Xiaoyan Lu, W. Gerald Teague, Neely Kazerouni2, Larry J. Anderson, and Dean D. ErdmanComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (N. Khetsuriani, X. Lu, N. Kazerouni, L.J. Anderson, D.D. Erdman); Emory University School of Medicine, Atlanta (W.G. Teague);

Main Article

Table 2

Human rhinoviruses identified in 53 pediatric patients with asthma, March 2003–February 2004, Atlanta, Georgia, USA*

HRVs
 Receptor-binding group
 No. among all HRV+ patients, n = 53
 No. among HRV+ case-patients, n = 39
 No. among HRV+ controls, n = 14
Virus symptoms, 
n = 20
 No virus symptoms, n = 19
Total no. genotyped† 29 17 7 5
Species A 18 12 3 3
HRV12 Major 1 1 0 0
HRV30 Minor 2 2 0 0
HRV36 Major 1 0 1 0
HRV39 Major 1 0 0 1
HRV43 Major 1 1 0 0
HRV44 Minor 2 1 0 1
HRV46 Major 1 1 0 0
HRV49 Minor 2 1 1 0
HRV53 Major 1 0 1 0
HRV54 Major 1 1 0 0
HRV61 Major 1 1 0 0
HRV65 Major 1 1 0 0
HRV66 Major 1 0 0 1
HRV68 Major 1 1 0 0
GA23584‡
 Unknown
 1
 1
 0
 0
Species B 3 1 0 2
HRV48 Major 1 0 0 1
HRV99
 Major
 2
 1
 0
 1
Genogroup C§
 Unknown
 8
 4
 4
 0
Not genotyped Unknown 24 3 12 9

*HRV, human rhinovirus; case-patients, asthma patients with exacerbations; controls, asthma patients without exacerbation.
†HRV genotype based on partial virus capsid protein (VP1) gene sequence. Serotype designation based on >90% VP1 amino acid sequence identity with respective prototype strains.
‡Strain GA23584 showed 73.0% amino acid sequence identity with HRV80.
§Genogroup C HRVs form a clade phylogenetically distict from species A and B HRVs.

Main Article

1Part of the information in this article was presented at the International Conference of the American Thoracic Society, May 16–21, 2008, Toronto, Ontario, Canada.

2Current affilation: California Department of Public Health, Richmond, California, USA.

Page created: July 18, 2010
Page updated: July 18, 2010
Page reviewed: July 18, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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