Volume 14, Number 4—April 2008
CME ACTIVITY - Research
β-Herpesviruses in Febrile Children with Cancer
Stephanie Yee-Guardino*, Kate Gowans*, Belinda Yen-Lieberman†, Pamela Berk†, Debra Kohn†, Fu-Zhang Wang†1, Lara Danziger-Isakov*†, Camille Sabella*†, Sarah Worley†, Philip E. Pellett†2
, and Johanna Goldfarb*†
, and Johanna Goldfarb*†
Table 2
Detection of β-herpesviruses in cancer patients and solid-organ transplant recipients*
| Characteristic | Cancer patients, no. positive/no. tested (%) |
Transplant patients (n = 9), no. positive/no. tested (%) | |
|---|---|---|---|
| Leukemia (n = 9) | Solid tumor (n = 20) | ||
| CMV PCR | |||
| Whole blood | 1/6 (17) | 0/5 | 3/7 (43) |
| PBMC | 1/7 (14) | 0/16 | 2/8 (25) |
| Plasma | 0/9 | 0/20 | 2/9 (22) |
| All tests |
1/9 (11) |
0/20 (0) |
3/9 (33) |
| HHV-6 PCR | |||
| Whole blood | 2/6 (33) | 0/5 | 2/7 (29) |
| PBMC | 1/7 (14) | 1/16 (6) | 3/8 (38) |
| Plasma | 0/9 | 0/19 | 1/9 (11) |
| Lymphocyte culture | 1/8 (13) | 0/16 | 0/9 |
| All tests |
3/9 (33) |
1/20 (5) |
3/9 (33) |
| HHV-7 PCR | |||
| Whole blood | 0/6 | 0/5 | 0/7 |
| PBMC | 0/7 | 0/16 | 0/8 |
| Plasma | 0/9 | 0/20 | 0/9 |
| All tests | 0/9 | 0/20 | 0/9 |
*Data are not shown for study participant 23, a patient with lymphoma who did not have β-herpesviruses detected in whole blood, PBMC, or plasma. CMV, cytomegalovirus; PBMC, peripheral blood mononuclear cells; HHV-6, human herpesvirus 6.
1Current affiliation: University of North Carolina, Chapel Hill, North Carolina, USA
2Current affiliation: Wayne State University School of Medicine, Detroit, Michigan, USA
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