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Volume 14, Number 4—April 2008
Research

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Boris Klempa*†2, Evgeniy A. Tkachenko‡2, Tamara K. Dzagurova‡, Yulia V. Yunicheva‡, Vyacheslav G. Morozov‡, Natalia M. Okulova‡, Galina P. Slyusareva‡, Aleksey Smirnov‡, and Detlev H. Kruger*Comments to Author 

Author affiliations: *Charité School of Medicine, Berlin, Germany; †Slovak Academy of Sciences, Bratislava, Slovakia; ‡Russian Academy of Medical Sciences, Moscow, Russia;

Main Article

Table 3

Severity of clinical disease for 126 patients with Dobrava-Belgrade–associated hemorrhagic fever with renal syndrome, Russia*

Characteristic Severity†
Mild Moderate Severe
Clinical sign or symptom
Maximum temperature, °C <38.0 38.0–39.5 >39.5
Headache –/+ +/++ +++/++++
Vision disturbance – –/+ +/++
Low-back, abdominal pain –/+ +/++ +++/++++
Hemorrhagic (petechial) skin rash – –/+ –/+/++
Oliguria (minimum mL/d) >900 300–900 <200–300
Oliguria duration, d 6 9 11–13
Maximum blood urea, mmol/L <8.3 8.3–19.0 >19.0
Maximum blood creatinine, μmol/L <130 130–300 >300
Maximum leukocyte count, 109/L
 <8.0
 8.0–14.0
 >14.0
Clinical outcome by region
Sochi (2000–2006) 6% 39% 55%
Lipetsk (2001–02) 19% 54% 27%

*Boldface indicates statistically significant differences between groups. Comparison of binomial population proportions analysis implemented in Statlets (NWP Associates, Inc.; www.mrs.umn.edu/~sungurea/statlets/statlets.htm) indicates that the null hypothesis that the 2 proportions are equal could be rejected at significance level of 5.0%.
†According to Leshchinskaia et al. (34).

Main Article

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Main Article

1This work is dedicated to the memory of our friend and colleague Milan Labuda, who died in August 2007.

2These authors contributed equally to this article.

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