Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 14, Number 4—April 2008
Research

Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Boris Klempa*†2, Evgeniy A. Tkachenko‡2, Tamara K. Dzagurova‡, Yulia V. Yunicheva‡, Vyacheslav G. Morozov‡, Natalia M. Okulova‡, Galina P. Slyusareva‡, Aleksey Smirnov‡, and Detlev H. Kruger*Comments to Author 

Author affiliations: *Charité School of Medicine, Berlin, Germany; †Slovak Academy of Sciences, Bratislava, Slovakia; ‡Russian Academy of Medical Sciences, Moscow, Russia;

Main Article

Table 5

Results of typing of neutralizing antibodies in serum from patients with Dobrava-Belgrade virus–associated hemorrhagic fever with renal syndrome, Russia

Region Sample no. Time after onset of disease FRNT titer* against
Sochi/Ap Lipetsk/Aa Slo/Af SK/Aa HTNV SEOV PUUV
Sochi (2000–2006)
 1,312 104 d 2,560 80 160 ND 160 <80 <40
3,692 30 d 1,280 160 160 ND <80 <80 <40
1,291 16 d 640 160 160 ND 40 40 <40
4,714 1 y, 5 mo >20,480 5,120 5,120 ND 320 320 <40
1,310 50 d 2,560 640 640 ND 160 160 <40
1,307 15 d 640 320 320 ND 160 160 <40
4,716 5 y, 3 mo 5,120 1,280 2,560 ND 160 <80 <40
4,715
 1 y, 4 mo
 5,120
 2,560
 5,120
 ND
 ND
 ND
 <40
Lipetsk (2001–2002)
 4,338 6 mo 160 640 160 320 ND† ND† ND†
3,894 21 d 40 640 40 160 ND† ND† ND†
4,334 3 y, 6 mo 160 640 320 160 ND† ND† ND†
4,344 6 mo 160 640 320 640 ND† ND† ND†
3,958 3 mo 20 80 80 40 ND† ND† ND†
4,329
 3 y, 4 mo
 640
 640
 2,560
 640
 ND†
 ND†
 ND†
Slovakia B38 3 y, 9 mo 2,560 640 5,120 2,560 40 640 40
B39 3 y, 9 mo 2,560 1,280 10,240 2,560 160 160 40

*FRNT, focus-reduction neutralization test. Reciprocal end-point titers are given as determined by chemiluminescence FRNT. ND, not determined.
†Serum previously characterized as anti–Dobrava-Belgrade virus (DOBV) in a first FRNT investigation with Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), and DOBV–Slo/Af only.

Main Article

1This work is dedicated to the memory of our friend and colleague Milan Labuda, who died in August 2007.

2These authors contributed equally to this article.

Page created: July 14, 2010
Page updated: July 14, 2010
Page reviewed: July 14, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external