Volume 15, Number 1—January 2009
Perspective
Threat of Dengue to Blood Safety in Dengue-Endemic Countries
Table
Reported healthcare-associated transmission of flaviviruses
Virus | Route of transmission | Comment | References |
---|---|---|---|
Dengue | Percutaneous | Several healthcare workers were infected after needlestick injuries during care of returned travelers who had diagnoses of dengue. | (8,10–13) |
Mucocutaneous | A healthcare worker became infected with dengue 3 virus after being splashed in the face by blood from a febrile traveler who had a diagnosis of dengue. | (7,14) | |
Blood transfusion | A 17-year-old man from Hong Kong, Special Administrative Region, People’s Republic of China, donated blood in July 2002, from which erythrocytes were transfused to a 72-year-old woman, in whom febrile illness consistent with dengue fever developed 3 d later. | (15) | |
Bone marrow transplant | A 6-year-old child from Puerto Rico became infected with dengue 4 virus from a bone marrow transplant and died. | (16) | |
Renal transplant |
Dengue hemorrhagic fever developed after a living donor renal transplant. |
(17) |
|
Yellow fever |
Laboratory |
A laboratory technician acquired yellow fever after obtaining blood and performing a blood count on a yellow fever patient; he died subsequently. Yellow fever was transmitted to at least 30 other scientists and laboratory workers after contact with mouse or monkey blood or tissues or handling infected animals. |
(18–20) |
West Nile | Percutaneous | Virus was transmitted to 2 microbiologists by laceration or needlestick injuries in laboratory. | (21) |
Transfusion | Virus was transmitted to numerous recipients of blood products. | (22,23) | |
Organ transplant | Virus was transmitted to transplant recipients from kidneys, liver, and heart of an infected donor. | (24) | |
Hemodialysis | Virus infection in a cluster of 3 hemodialysis patients suggested transmission through a common dialysis machine. | (25) |
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