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Volume 15, Number 10—October 2009
Research

A Model-based Assessment of Oseltamivir Prophylaxis Strategies to Prevent Influenza in Nursing Homes

Carline van den DoolComments to Author , Eelko Hak, Marc J.M. Bonten1, and Jacco Wallinga1
Author affiliations: University Medical Center, Utrecht, the Netherlands (C. van den Dool, E. Hak, M.J.M. Bonten, J. Wallinga); University Medical Center, Groningen, the Netherlands (E. Hak); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (J. Wallinga)

Main Article

Figure 1

Schematic diagram of our stochastic individual-based model. A) The different types of persons in the nursing home: patients, healthcare workers (HCWs), and visitors. B) The time course of infection: S, susceptible; E, exposed; Ia, infectious and asymptomatic; Is, infectious and symptomatic; R, recovered/immune; Rp, immune while using prophylaxis. For all patients and HCWs in the model, we kept track of their stage in this infection cycle in time. If the influenza strain that is transmitted is re

Figure 1. Schematic diagram of our stochastic individual-based model. A) The different types of persons in the nursing home: patients, healthcare workers (HCWs), and visitors. B) The time course of infection: S, susceptible; E, exposed; Ia, infectious and asymptomatic; Is, infectious and symptomatic; R, recovered/immune; Rp, immune while using prophylaxis. For all patients and HCWs in the model, we kept track of their stage in this infection cycle in time. If the influenza strain that is transmitted is resistant to oseltamivir, persons in the Rp department can still become infected (dashed arrow).

Main Article

1These authors contributed equally to this article.

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