Volume 16, Number 7—July 2010
Dispatch
Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues
Yoshifumi Iwamaru
, Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, and Takashi Yokoyama
, Morikazu Imamura, Yuichi Matsuura, Kentaro Masujin, Yoshihisa Shimizu, Yujing Shu, Megumi Kurachi, Kazuo Kasai, Yuichi Murayama, Shigeo Fukuda, Sadao Onoe, Ken’ichi Hagiwara, Yoshio Yamakawa, Tetsutaro Sata, Shirou Mohri, Hiroyuki Okada, and Takashi Yokoyama
Table
Western blot detection of PrPres in tissue samples obtained from cattle intracerebrally challenged with BSE/JP24 prion*
| Tissue samples | Cattle identification codes |
||||
|---|---|---|---|---|---|
| 8515 (10 mpi) | 498 (12 mpi) | 528 (16 mpi) | 1061 (16 mpi) | 5566 (16 mpi) | |
| Nerve tissues | |||||
| Obex | + | + | + | + | + |
| Spinal cord | + | + | + | + | + |
| Cauda equina | + | + | + | + | + |
| Optic nerve | + | + | + | + | + |
| Pituitary gland | + | + | + | + | + |
| Trigeminal ganglia | + | + | + | + | + |
| Cranial cervical ganglia | + | + | + | + | + |
| Stellate ganglia | + | + | + | + | + |
| Vagosympathic trunk | + | + | + | + | + |
| Cranial mesenteric ganglia | + | + | + | + | + |
| Vagus nerve | + | + | + | + | + |
| Facial nerve | − | − | − | − | − |
| Hypoglossal nerve | − | − | − | − | − |
| Phrenic nerve | − | + | + | + | + |
| Accessory nerve | − | + | + | + | + |
| Suprascapular nerve | − | − | + | + | + |
| Brachial nerve plexus | − | − | + | + | + |
| Median nerve | − | − | + | + | − |
| Radial nerve | − | − | + | + | − |
| Sciatic nerve | − | + | + | + | + |
| Tibial nerve | − | + | + | + | + |
| Adrenal gland |
− |
+ |
+ |
+ |
+ |
| Lymphoid tissues | |||||
| Spleen | − | − | − | − | − |
| Tonsil | − | − | − | − | − |
| Parotid lymph nodes | − | − | − | − | − |
| Lateral retropharyngeal lymph nodes | − | − | − | − | − |
| Mandibular lymph nodes | − | − | − | − | − |
| Brachiocephalic lymph node | − | − | − | − | − |
| Anterior cervical lymph node | − | − | − | − | − |
| Axillary lymph nodes | − | − | − | − | − |
| Superficial inguinal lymph nodes | − | − | − | − | − |
| Subiliac lymph nodes | − | − | − | − | − |
| Popliteal lymph nodes | − | − | − | − | − |
| Splenic lymph nodes | − | − | − | − | − |
| Hepatic lymph nodes | − | − | − | − | − |
| Internal iliac lymph nodes | − | − | − | − | − |
| External iliac lymph nodes | − | − | − | − | − |
| Mesenteric lymph nodes | − | − | − | − | − |
*PrPres, prion protein resistant; BSE, bovine spongiform encephalopathy; mpi, months postinoculation; +, positive for PrPres; –, negative for PrPres.
Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
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