Volume 4, Number 2—June 1998
Synopsis
Multiple-Drug Resistant Enterococci: The Nature of the Problem and an Agenda for the Future
Figure 3
References
- Kaye D. Enterococci: biologic and epidemiologic characteristics and in vitro susceptibility. Arch Intern Med. 1982;142:2006–9. DOIPubMedGoogle Scholar
- Emori TG, Gaynes RP. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin Microbiol Rev. 1993;6:428–42.PubMedGoogle Scholar
- Jarvis WR, Gaynes RP, Horan TC, Emori TG, Stroud LA, Archibald LK, Semiannual report: aggregated data from the National Nosocomial Infections Surveillance (NNIS) system. CDC, 1996:1-27.
- Cohen ML. Epidemiology of drug resistance: implications for a post-antimicrobial era. Science. 1992;257:1050–5. DOIPubMedGoogle Scholar
- Jett BD, Huycke MM, Gilmore MS. Virulence of enterococci. Clin Microbiol Rev. 1994;7:462–78.PubMedGoogle Scholar
- Rice EW, Messer JW, Johnson CH, Reasoner DJ. Occurrence of high-level aminoglycoside resistance in environmental isolates of enterococci. Appl Environ Microbiol. 1995;61:374–6.PubMedGoogle Scholar
- Devriese LA, Pot B, Collins MD. Phenotypic identification of the genus Enterococcus and differentiation of phylogenetically distinct enterococcal species and species groups. J Appl Bacteriol. 1993;75:399–408.PubMedGoogle Scholar
- Willett HP. Energy metabolism. In: Joklik WK, Willett HP, Amos DB, Wilfert CM, editors. Zinsser microbiology. 20th ed. East Norwalk (CT): Appleton & Lange; 1992. p. 53-75.
- Ritchey TW, Seeley HW. Cytochromes in Streptococcus faecalis var. zymogenes grown in a haematin-containing medium. J Gen Microbiol. 1974;85:220–8.PubMedGoogle Scholar
- Pritchard GG, Wimpenny JWT. Cytochrome formation, oxygen-induced proton extrusion and respiratory activity in Streptococcus faecalis var. zymogenes grown in the presence of haematin. J Gen Microbiol. 1978;104:15–22.PubMedGoogle Scholar
- Ritchey TW, Seeley HW Jr. Distribution of cytochrome-like respiration in streptococci. J Gen Microbiol. 1976;93:195–203.PubMedGoogle Scholar
- Bryan-Jones DG, Whittenbury R. Haematin-dependent oxidative phosphorylation in Streptococcus faecalis. J Gen Microbiol. 1969;58:247–60.PubMedGoogle Scholar
- Williamson R. Le Bougu,nec C, Gutmann L, Horaud T. One or two low affinity penicillin-binding proteins may be responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin. J Gen Microbiol. 1985;131:1933–40.PubMedGoogle Scholar
- Bush LM, Calmon J, Cherney CL, Wendeler M, Pitsakis P, Poupard J, High-level penicillin resistance among isolates of enterococci: implications for treatment of enterococcal infections. Ann Intern Med. 1989;110:515–20.PubMedGoogle Scholar
- Sapico FL, Canawati HN, Ginunas VJ, Gilmore DS, Montgomerie JZ, Tuddenham WJ, Enterococci highly resistant to penicillin and ampicillin: an emerging clinical problem? J Clin Microbiol. 1989;27:2091–5.PubMedGoogle Scholar
- Horodniceanu T, Bougueleret L, El-Solh N, Bieth G, Delbos F. High-level, plasmid-borne resistance to gentamicin in Streptococcus faecalis subsp zymogenes. Antimicrob Agents Chemother. 1979;16:686–9.PubMedGoogle Scholar
- Zervos MJ, Kauffman CA, Therasse PM, Bergman AG, Mikesell TS, Schaberg DR. Nosocomial infection by gentamicin-resistant Streptococcus faecalis: an epidemiologic study. Ann Intern Med. 1987;106:687–91.PubMedGoogle Scholar
- Murray BE, Singh KV, Markowitz SM, Lopardo HA, Patterson JE, Zervos MJ, Evidence for clonal spread of a single strain of ß-lactamase-producing Enterococcus (Streptococcus) faecalis to six hospitals in five states. J Infect Dis. 1991;163:780–5.PubMedGoogle Scholar
- Uttley AHC, Collins CH, Naidoo J, George RC. Vancomycin-resistant enterococci. Lancet. 1988;1:57–8. DOIPubMedGoogle Scholar
- Leclercq R, Derlot E, Duval J, Courvalin P. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med. 1988;319:157–61.PubMedGoogle Scholar
- Sahm DF, Kissinger J, Gilmore MS, Murray PR, Mulder R, Solliday J, In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis. Antimicrob Agents Chemother. 1989;33:1588–91.PubMedGoogle Scholar
- Arthur M, Courvalin P. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993;37:1563–71.PubMedGoogle Scholar
- Clark NC, Cooksey RC, Hill BC, Swenson JM, Tenover FC. Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob Agents Chemother. 1993;37:2311–7.PubMedGoogle Scholar
- Klare I, Heier H, Claus H, Reissbrodt R, Van Witte W. A-mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry. FEMS Microbiol Lett. 1995;125:165–72. DOIPubMedGoogle Scholar
- Noble WC, Virani Z, Cree RGA. Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol Lett. 1992;93:195–8. DOIGoogle Scholar
- Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother. 1997;40:135–46. DOIPubMedGoogle Scholar
- Haley RW, Culver DH, White JW, Meade WM, Emori TG, Munn VP, The efficacy of infection surveillance and control programs in preventing nosocomial infections in US hospitals. Am J Epidemiol. 1985;121:182–205.PubMedGoogle Scholar
- Harris SL. Definitions and demographic characteristics. In: Kaye D, editor. Infective endocarditis. New York: Raven Press, Ltd.; 1992. p. 1-18.
- Hughes JM, Culver DH. W, Morgan WM, Munn VP, Mosser JL, Emori TG. Nosocomial infection surveillance, 1980-1982. MMWR Morb Mortal Wkly Rep 1983;32:1SS-16SS.
- Edmond MB, Ober JF, Dawson JD, Weinbaum DL, Wenzel RP. Vancomycin-resistant enterococcal bacteremia: natural history and attributable mortality. Clin Infect Dis. 1996;23:1234–9.PubMedGoogle Scholar
- Rhinehart E, Smith NE, Wennersten C, Gorss E, Freeman J, Eliopoulos GM, Rapid dissemination of ß-lactamase-producing, aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward. N Engl J Med. 1990;26:1814–8.
- Chow JW, Kuritza A, Shlaes DM, Green M, Sahm DF, Zervos MJ. Clonal spread of vancomycin-resistant Enterococcus faecium between patients in three hospitals in two states. J Clin Microbiol. 1993;31:1609–11.PubMedGoogle Scholar
- Montecalvo MA, Horowitz H, Gedris C, Carbonaro C, Tenover FC, Issah A, Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faecium bacteremia in an adult oncology unit. Antimicrob Agents Chemother. 1994;38:1363–7.PubMedGoogle Scholar
- Livornese LL, Dias S, Samel C, Romanowski B, Taylor S, May P, Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann Intern Med. 1992;117:112–6.PubMedGoogle Scholar
- Handwerger S, Raucher B, Altarac D, Monka J, Marchione S, Singh KV, Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin Infect Dis. 1993;16:750–5.PubMedGoogle Scholar
- Centers for Disease Control and Prevention. Recommendations for preventing the spread of vancomycin resistance: recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Morb Mortal Wkly Rep. 1995;44(No. RR-12):1–13.PubMedGoogle Scholar
- Morris JG Jr, Shay DK, Hebden JN, McCarter RJ Jr, Perdue BE, Jarvis W, Enterococci resistant to multiple antimicrobial agents, including vancomycin. Ann Intern Med. 1995;123:250–9.PubMedGoogle Scholar
- Edmond MB, Ober JF, Weinbaum DL, Pfaller MA, Hwang T, Sanford MD, Vancomycin-resistant Enterococcus faecium bacteremia: risk factors for infection. Clin Infect Dis. 1995;20:1126–33.PubMedGoogle Scholar
- Goldmann D, Larson E. Hand-washing and nosocomial infections. N Engl J Med. 1992;327:120–2.PubMedGoogle Scholar
- Noskin GA, Stosor V, Cooper I, Peterson LR. Recovery of vancomycin-resistant enterococci on fingertips and environmental surfaces. Infect Control Hosp Epidemiol. 1995;16:577–81. DOIPubMedGoogle Scholar
- Vollaard EJ, Clasener HAL. Colonization resistance. Antimicrob Agents Chemother. 1994;38:409–14.PubMedGoogle Scholar
- Quale J, Landman D, Saurina G, Atwood E, DiTore V, Patel K. Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci. Clin Infect Dis. 1996;23:1020–5.PubMedGoogle Scholar
- Caron F, Pestel M, Kitzis M-D, Lemeland JF, Humbert G, Gutmann L. Comparison of different ß-lactam-glycopeptide-gentamicin combinations for an experimental endocarditis caused by a highly ß-lactam-resistant and highly glycopeptide-resistant isolate of Enterococcus faecium. J Infect Dis. 1995;171:106–12.PubMedGoogle Scholar
- Norris AH, Reilly JP, Edelstein PH, Brennan PJ, Schuster MG. Chloramphenicol for the treatment of vancomycin-resistant enterococcal infections. Clin Infect Dis. 1995;20:1137–44.PubMedGoogle Scholar
- Cohen MA, Yoder SL, Huband MD, Roland GE, Courtney CL. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob Agents Chemother. 1995;39:2123–7.PubMedGoogle Scholar
- Aumercier M, Bouhallab S, Capmau M-L, LeGoffic F. RP 59500: A proposed mechanism for its bactericidal activity. J Antimicrob Chemother. 1992;30(Suppl A):9–14.PubMedGoogle Scholar
- Collins LA, Malanoski GJ, Eliopoulos GM, Wennersten CB, Ferraro MJ, Moellering RC Jr. In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms. Antimicrob Agents Chemother. 1993;37:598–601.PubMedGoogle Scholar
- Chow JW, Davidson A, Sanford E III, Zervos MJ. Superinfection with Enterococcus faecalis during quinupristin/dalfopristin therapy. Clin Infect Dis. 1997;24:91–2.PubMedGoogle Scholar
- Chow JW, Donahedian SM, Zervos MJ. Emergence of increased resistance to quinupristin/dalfopristin during therapy for Enterococcus faecium bacteremia. Clin Infect Dis. 1997;24:90–1.PubMedGoogle Scholar
- Eliopoulos GM, Wennersten CB, Cole G, Moellering RC. In vitro activities of two glycylcyclines against gram-positive bacteria. Antimicrob Agents Chemother. 1994;38:534–41.PubMedGoogle Scholar
- Jones RN, Johnson DM, Erwin ME. In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones. Antimicrob Agents Chemother. 1996;40:720–6.PubMedGoogle Scholar
- Hillyard DR. The molecular approach to microbial diagnosis. Am J Clin Pathol. 1994;101:S18–21.PubMedGoogle Scholar
- Strohl WR. Biotechnology of Antibiotics. 2nd ed: Drugs and the Pharmaceutical Sciences 82, 1997.
- Jett BD, Jensen HG, Nordquist RE, Gilmore MS. Contribution of the pAD1-encoded cytolysin to the severity of experimental Enterococcus faecalis endophthalmitis. Infect Immun. 1992;60:2445–52.PubMedGoogle Scholar
- Ike Y, Hashimoto H, Clewell DB. High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infections. J Clin Microbiol. 1987;25:1524–8.PubMedGoogle Scholar
- Huycke MM, Spiegel CA, Gilmore MS. Bacteremia caused by hemolytic, high-level gentamicin-resistant Enterococcus faecalis. Antimicrob Agents Chemother. 1991;35:1626–34.PubMedGoogle Scholar
- Jett BD, Jensen HG, Atkuri R, Gilmore MS. Evaluation of therapeutic measures for treating endophthalmitis cause by isogenic toxin producing and toxin non-producing Enterococcus faecalis strains. Invest Ophthalmol Vis Sci. 1995;36:9–15.PubMedGoogle Scholar
- Ike Y, Hashimoto H, Clewell DB. Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice. Infect Immun. 1984;45:528–30.PubMedGoogle Scholar
- Chow JW, Thal LA, Perri MB, Vazquez JA, Donabedian SM, Clewell DB, Plasmid-associated hemolysin and aggregation substance production contributes to virulence in experimental enterococcal endocarditis. Antimicrob Agents Chemother. 1993;37:2474–7.PubMedGoogle Scholar
- Ike Y, Clewell DB. Genetic analysis of pAD1 pheromone response in Streptococcus faecalis using transposon Tn917 as an insertional mutagen. J Bacteriol. 1984;158:777–83.PubMedGoogle Scholar
- Ike Y, Clewell DB, Segarra RA, Gilmore MS. Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and cloning. J Bacteriol. 1990;172:155–63.PubMedGoogle Scholar
- Huycke MM, Gilmore MS. Frequency of aggregation substance and cytolysin genes among enterococcal endocarditis isolates. Plasmid. 1995;34:152–6. DOIPubMedGoogle Scholar
- Todd EW. A comparative serological study of streptolysins derived from human and from animal infections, with notes on pneumococcal haemolysin, tetanolysin and staphylococcus toxin. J Pathol Bacteriol. 1934;39:299–321. DOIGoogle Scholar
- Booth MC, Bogie CP, Sahl H-G, Siezen RJ, Hatter KL, Gilmore MS. Structural analysis and proteolytic activation of Enterococcus faecalis cytolysin, a novel lantibiotic. Mol Microbiol. 1996;21:1175–84. DOIPubMedGoogle Scholar
- Gilmore MS, Segarra RA, Booth MC. An hlyB-type function is required for expression of the Enterococcus faecalis hemolysin/bacteriocin. Infect Immun. 1990;58:3914–23.PubMedGoogle Scholar
- Katz L, Chu DT, Reich K. Bacterial genomics and the search for novel antibiotics. In: Plattner JJ, editor. Annual Reports in Medicinal Chemistry. Vol. 32. New York: Academic Press, Inc., 1997. p. 121-30.
- Shankar V, Gilmore MS. Structure and expression of a novel surface protein of Enterococcus faecalis. In: Abstracts of the 97th General Meeting of the American Society for Microbioloty; 4-8 May 1997;Miami Beach, Florida. Washington: The Society; 1997.
- Hancock LE, Gilmore MS. The contribution of a cell wall associated carbohydrate to the in vivo survival of Enterococcus faecalis in a murine model of infection. In: Abstracts of the 97th General Meeting of the American Society for Microbioloty. 4-8 May 1997;Miami Beach, Florida. Washington: The Society; 1997.
- Arduino RC, Murray BE, Rakita RM. Roles of antibodies and complement in phagocytic killing of enterococci. Infect Immun. 1994;62:987–93.PubMedGoogle Scholar
- Arduino RC, Palaz-Jacques K, Murray BE, Rakita RM. Resistance of Enterococcus faecium to neutrophil-mediated phagocytosis. Infect Immun. 1994;62:5587–94.PubMedGoogle Scholar
- Huycke MM, Joyce W, Wack MF. Augmented production of extracellular superoxide production by blood isolates of Enterococcus faecalis. J Infect Dis. 1996;173:743–6.PubMedGoogle Scholar
- Swartz MN. Hospital-acquired infections: diseases with increasingly limited therapies. Proc Natl Acad Sci U S A. 1994;91:2420–7. DOIPubMedGoogle Scholar
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