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Volume 6, Number 5—October 2000
Dispatch

Antimicrobial-Drug Use and Changes in Resistance in Streptococcus pneumoniae

Daniel J. DiekemaComments to Author , Angela B. Brueggemann, and Gary V. Doern
Author affiliations: University of Iowa College of Medicine, Iowa City, Iowa

Main Article

Table 3

Mean increase in percent penicillin resistancea of Streptococcus pneumoniae by categoryb of antimicrobial-drug use

Class High Intermediate Low p-valuec
Beta-lactams 13.3 8.8 2.8 0.20
Quinolones 13.0 6.3 5.3 0.39
Macrolides 4.0 12.4 8.9 0.39
Tetracyclines 5.3 7.7 11.8 0.56
All classes 13.3 3.3 7.6 0.27

aIncludes both intermediate- (MIC 0.12-1 g/mL) and high-level (MIC >2 g/mL) resistance to penicillin.
bEach center was categorized by total number of outpatient prescriptions for the antimicrobial class per 100,000 population per month in the surrounding metropolitan statistical area.
cOne-way ANOVA p-value, two-tailed.

Main Article

Page created: December 17, 2010
Page updated: December 17, 2010
Page reviewed: December 17, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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