Volume 9, Number 7—July 2003
Research
Emergence and Global Spread of a Dengue Serotype 3, Subtype III Virus
Figure 4

Figure 4. Global spread of dengue virus 3 (DENV-3), subtype III, which has been continuously circulating in the Indian subcontinent from the 1960s to the present. The virus was first isolated from East Africa in 1985 in Mozambique and subsequently from Kenya (1991) and Somalia (1993) (32,33). DENV-3 subtype III was first detected in the American continent in 1994 (Nicaragua and Panama) and the virus has subsequently spread through most of Latin America (13,14,16,29,30). The arrows depict the most likely directions of spread based on the phylogenetic relationships between the viruses (see text for details). The map also displays countries in which dengue is known to occur.
References
- Briese T, Jia XY, Huang C, Grady LJ, Lipkin WI. Identification of a Kunjin/West Nile–like flavivirus in brains of patients with New York encephalitis. Lancet. 1999;354:1261–2. DOIPubMedGoogle Scholar
- Lanciotti RS, Roehrig JT, Deubel V, Smith J, Parker M, Steele K, Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science. 1999;286:2333–7. DOIPubMedGoogle Scholar
- Morse SS. Emerging viruses. New York: Oxford University Press; 1993.
- Halstead SB. Epidemiology of dengue and dengue hemorrhagic fever. In: Kuno DJGaG, editor. Dengue and dengue hemorrhagic fever. New York: CAB International; 1997. p. 23–44.
- Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11:480–96.PubMedGoogle Scholar
- Rosen L. The emperor’s new clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever. Am J Trop Med Hyg. 1977;26:337–43.PubMedGoogle Scholar
- Gubler DJ, Reed D, Rosen L, Hitchcock JR Jr. Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga. Am J Trop Med Hyg. 1978;27:581–9.PubMedGoogle Scholar
- Gubler DJ, Suharyono W, Lubis I, Eram S, Gunarso S. Epidemic dengue 3 in central Java, associated with low viremia in man. Am J Trop Med Hyg. 1981;30:1094–9.PubMedGoogle Scholar
- Guzman MG, Kouri GP, Bravo J, Soler M, Velasquez S, Morier L. Dengue haemorrhagic fever in Cuba. A retrospective seroepidemiologic study. Am J Trop Med Hyg. 1990;42:179–84.PubMedGoogle Scholar
- Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997;230:244–51. DOIPubMedGoogle Scholar
- Dengue type 3 infection. Nicaragua and Panama, October–November 1994. Wkly Epidemiol Rec. 1995;70:41–3.PubMedGoogle Scholar
- Gubler DJ. The global pandemic of dengue/dengue haemorrhagic fever: current status and prospects for the future. Ann Acad Med Singapore. 1998;27:227–34.PubMedGoogle Scholar
- Nogueira RM, Miagostovich MP, de Filippis AM, Pereira MA, Schatzmayr HG. Dengue virus type 3 in Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2001;96:925–6. DOIPubMedGoogle Scholar
- Chungue E, Deubel V, Cassar O, Laille M, Martin PM. Molecular epidemiology of dengue 3 viruses and genetic relatedness among dengue 3 strains isolated from patients with mild or severe form of dengue fever in French Polynesia. J Gen Virol. 1993;74:2765–70. DOIPubMedGoogle Scholar
- Leitmeyer KC, Vaughn DW, Watts DM, Salas RA, de Chacon IV, Ramos C, Dengue virus structural differences that correlate with pathogenesis. J Virol. 1999;73:4738–47.PubMedGoogle Scholar
- Srivastava VK, Suri S, Bhasin A, Srivastava L, Bharadwaj M. An epidemic of dengue haemorrhagic fever and dengue shock syndrome in Delhi: a clinical study. Ann Trop Paediatr. 1990;10:329–34.PubMedGoogle Scholar
- Vitarana UT, Jayasekera N, Withane N, Gubler DJ. Finding the cause of dengue hemorrhagic fever outbreaks in Sri Lanka. Arbovirus Research in Australia. 1993;6:125–9.
- Messer WB, Sivananthan K, Elvitigala J, Preethimala LD, Ramesh R, Withana N, Epidemiology of dengue in Sri Lanka before and after the emergence of epidemic dengue hemorrhagic fever. Am J Trop Med Hyg. 2002;66:765–73.PubMedGoogle Scholar
- de Silva AM, Sivananthan K, Withana N, Vorndam V, Gubler DJ. Dengue 3 virus is responsible for recent epidemics of dengue hemorrhagic fever in Sri Lanka. In: Annual Meeting of the American Society for Tropical Medicine and Hygiene. San Juan, Puerto Rico; 1998.
- Lanciotti RS, Lewis JG, Gubler DJ, Trent DW. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol. 1994;75:65–75. DOIPubMedGoogle Scholar
- Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology. 1997;230:244–51. DOIPubMedGoogle Scholar
- Kobayashi N, Thayan R, Sugimoto C, Oda K, Saat Z, Vijayamalar B, Type-3 dengue viruses responsible for the dengue epidemic in Malaysia during 1993–1994. Am J Trop Med Hyg. 1999;60:904–9.PubMedGoogle Scholar
- Rico-Hesse R. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology. 1990;174:479–93. DOIPubMedGoogle Scholar
- Lewis JA, Chang GJ, Lanciotti RS, Kinney RM, Mayer LW, Trent DW. Phylogenetic relationships of dengue-2 viruses. Virology. 1993;197:216–24. DOIPubMedGoogle Scholar
- Wang E, Ni H, Xu R, Barrett AD, Watowich SJ, Gubler DJ, Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J Virol. 2000;74:3227–34. DOIPubMedGoogle Scholar
- Briseno-Garcia B, Gomez-Dantes H, Argott-Ramirez E, Montesano R, Vazquez-Martinez AL, Ibanez-Bernal S, Potential risk for dengue hemorrhagic fever: the isolation of serotype dengue-3 in Mexico. Emerg Infect Dis. 1996;2:133–5. DOIPubMedGoogle Scholar
- Gubler DJ, Trent DW. Emergence of epidemic dengue/dengue hemorrhagic fever as a public health problem in the Americas. Infect Agents Dis. 1993;2:383–93.PubMedGoogle Scholar
- Gubler DJ, Suharyono W, Lubis I, Eram S, Sulianti Saroso J. Epidemic dengue hemorrhagic fever in rural Indonesia. I. Virological and epidemiological studies. Am J Trop Med Hyg. 1979;28:701–10.PubMedGoogle Scholar
- Lee E, Gubler DJ, Weir RC, Dalgarno L. Genetic and biological differentiation of dengue 3 isolates obtained from clinical cases in Java, Indonesia, 1976–1978. Arch Virol. 1993;133:113–25. DOIPubMedGoogle Scholar
- Kochel TJ, Watts DM, Halstead SB, Hayes CG, Espinoza A, Felices V. Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever. Lancet. 2002;360:310–2. DOIPubMedGoogle Scholar