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Volume 1, Number 3—July 1995
Dispatch

HIV-1 Patients May Harbor Viruses of Different Phylogenetic Subtypes: Implications for the Evolution of the HIV/AIDS Pandemic

Danuta Pieniazek*, Luiz M. Janini*#, Artur Ramos*#, Amilcar Tanuri#, Mauro Schechter, Jose M. Peralta#, Anna C.P. Vicente§, Norman J. Pieniazek*, Gerald Schochetman*, and Mark A. Rayfield*
Author affiliations: *National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA; 
#Universidade Federal do Rio de Janeiro, and Hospital Clementino Fraga Filho; §Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

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Figure 2

Phylogenetic classification of HIV-1 strains in dually infected patients. HIV-1 sequences from dual infections (Br5, 19, 20, and 22) are indicated by arrows, and the major strain in the infected child (Br30) is boxed. The tree was constructed on the basis of the DNA sequences of the protease gene by using the maximum likelihood method with the fast DNAml program (6). SIV-cpz protease sequence was used as an outgroup. The distinct HIV-1 subtypes are delineated. The scale bar shows the ratio of nu

Figure 2. Phylogenetic classification of HIV-1 strains in dually infected patients. HIV-1 sequences from dual infections (Br5, 19, 20, and 22) are indicated by arrows, and the major strain in the infected child (Br30) is boxed. The tree was constructed on the basis of the DNA sequences of the protease gene by using the maximum likelihood method with the fast DNAml program (6). SIV-cpz protease sequence was used as an outgroup. The distinct HIV-1 subtypes are delineated. The scale bar shows the ratio of nucleotide substitutions for given horizontal branch length. Vertical distances are for clarity only.

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