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Volume 1, Number 4—October 1995

Helicobacter hepaticus, a Recently Recognized Bacterial Pathogen, Associated with Chronic Hepatitis and Hepatocellular Neoplasia in Laboratory Mice

Jerry M. Rice
Author affiliation: Laboratory of Comparative Carcinogenesis, National
 Cancer Institute, Frederick, Maryland, USA

Main Article


Increasing prevalence of hepatitis and hepatocellular neoplasia in control male A/JCr mice at the National Cancer Institute's Frederick Cancer Research and Development Center, 1989-1992a

Date Killed Number of mice Age, in weeks Mice with hepatitis (%) Mice with liver tumors (%)
Jan-Mar 1989 48 47±3 0 0
May-Jul 1989 47 70±360 0 1 (2)
Jan-Apr 1992 6 36±34 2 (33) 0
Jul 1992 16 54 16 (100) 1 (6)
Aug-Oct 1992 64±3 5 (83) 3 (50)
Dec 1992 77 12 (100) 11 (92)

Adapted from ref. 4.

Main Article

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