Volume 10, Number 8—August 2004
Perspective
Genomic-scale Analysis of Bacterial Gene and Protein Expression in the Host
John D. Boyce*
, Paul A. Cullen*, and Ben Adler*
, Paul A. Cullen*, and Ben Adler*
Table
Large-scale measurement of bacterial gene or protein expression during real infections or interactions with host cells
| Species | Experiment type | Description | Reference |
|---|---|---|---|
| Growth in the host | |||
| Borrelia burgdorferi | DNA microarray | Growth in dialysis membranes implanted in rats | 18 |
| DNA microarray | Adaptation to growth in dialysis membranes in rats | 19 | |
| DNA microarray | Alteration of lipoprotein expression during host adaptation in mice | 20 | |
| Antigenic profiling | Alteration of antigenic profile during host adaptation in mice | 21 | |
| Pasteurella multocida | DNA microarray | Gene expression during growth in blood of infected chickens | 15 |
| DNA microarray | Gene expression during growth in livers of infected chickens | 14 | |
| Vibrio cholerae | DNA microarray | Gene expression during growth in rabbit ileal loops | 16 |
| DNA microarray | Gene expression in rice water stools | 17 | |
| Interaction with tissue culture cells | |||
| Chlamydia pneumoniae | 2-dimensional gel electrophoresis | Protein expression during growth in HEp-2 cells in response to interferon-γ | 22 |
| Neisseria meningitidis | DNA microarray | Interaction with epithelial and endothelial cells | 24 |
| DNA microarray | Interaction with epithelial cells | 23 |
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