Volume 10, Number 9—September 2004
Research
Silent Nucleotide Polymorphisms and a Phylogeny for Mycobacterium tuberculosis
Lucy Baker*, Tim Brown*, Martin Maiden†, and Francis Drobniewski*
Table 3
Characteristic features of the four major lineages of Mycobacterium tuberculosis with respect to M. bovis
| Species/lineage | TbD1 region of difference | Silent single nucleotide polymorphism |
Nonsynonymous base substitutions |
Spoligotype signature spacer deletion | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rpoB 3243 T | rpoB 2646 G | katG 87 A | katG 609 T | oxyR 285 A | oxyR 37 T | katG 1388 G | ahpC –46 A | |||
| M. tuberculosis Lineage I | – | – | – | – | – | – | – | – | – | 1–34 |
| M. tuberculosis Lineage II | – | + | – | – | – | – | – | + | – | 33–36 |
| M. tuberculosis Lineage III | – | – | + | – | – | – | – | – | + | 4–8, 23–24 |
| M. tuberculosis Lineage IV | + | – | – | – | – | – | + | – | – | 29–32 and 34 |
| M. bovis | + | – | – | + | + | + | – | – | – | 39–43 |
Page created: March 30, 2011
Page updated: March 30, 2011
Page reviewed: March 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.