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Volume 10, Number 9—September 2004

Silent Nucleotide Polymorphisms and a Phylogeny for Mycobacterium tuberculosis

Lucy Baker*, Tim Brown*, Martin Maiden†, and Francis Drobniewski*Comments to Author 
Author affiliations: *Heal Protection Agency, London, UK; †University of Oxford, Oxford, UK

Main Article

Table 3

Characteristic features of the four major lineages of Mycobacterium tuberculosis with respect to M. bovis

Species/lineage TbD1 region of difference Silent single nucleotide polymorphism
Nonsynonymous base substitutions
Spoligotype signature spacer deletion
T rpoB
G katG
A katG
T oxyR
A oxyR
T katG
G ahpC
M. tuberculosis Lineage I 1–34
M. tuberculosis Lineage II + + 33–36
M. tuberculosis Lineage III + + 4–8, 23–24
M. tuberculosis Lineage IV + + 29–32 and 34
M. bovis + + + + 39–43

Main Article

Page created: March 30, 2011
Page updated: March 30, 2011
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