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Volume 11, Number 10—October 2005


Botulinum Neurotoxin Detection and Differentiation by Mass Spectrometry

John R. Barr*Comments to Author , Hercules Moura*, Anne E. Boyer*, Adrian R. Woolfitt*, Suzanne R. Kalb*, Antonis Pavlopoulos*, Lisa G. McWilliams†, Jurgen G. Schmidt‡, Rodolfo A. Martinez‡, and David C. Ashley*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Battelle Memorial Institute, Atlanta, Georgia, USA; ‡Los Alamos National Laboratory, Los Alamos, New Mexico, USA

Main Article


Accuracy of quantification of BoNT-A*

Spike level (mouse LD50) Measured concentration mean SD (N = 4)
16 19.85 ± 1.71
32 33.75 ± 3.24
65 68.05 ± 5.07
125 120.78 ± 2.66

*BoNT, botulinum neurotoxin; LD, lethal dose; SD, standard deviation.

Main Article