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Volume 11, Number 11—November 2005


Neutralizing Antibody Response and SARS Severity

Mei-Shang Ho*, Wei-Ju Chen*, Hour-Young Chen†, Szu-Fong Lin†, Min-Chin Wang†, Jiali Di†, Yen-Ta Lu‡, Ching-Lung Liu‡, Shan-Chwen Chang§, Chung-Liang Chao¶, Chwan-Chuen King§, Jeng-Min Chiou*, Ih-Jen Su#, and Jyh-Yuan Yang†Comments to Author 
Author affiliations: *Academia Sinica, Taipei, Taiwan; †Center for Disease Control, Taipei, Taiwan; ‡Taipei Mackay Memorial Hospital, Taipei, Taiwan; §National Taiwan University, Taipei, Taiwan; ¶Taipei Hospital, Taipei, Taiwan; #National Health Research Institutes, Taipei, Taiwan

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Table 2

Comparison of SARS antibody results of ELISA and neutralization assay*

ELISA† Neutralizing antibody‡
Positive Negative
Positive 207 1
Negative 10 206
Total 217 207

*SARS, severe acute respiratory syndrome; ELISA, enzyme-linked immunosorbent assay.
†Reagents were supplied by Thomas Ksiazek, Centers for Disease Control and Prevention, Atlanta, GA, USA (2 reagents).
‡Using ELISA as the reference assay, the sensitivity of the neutralizing antibody (NT) test = 99.5%, the specificity of neutralizing antibody = 95.4%.

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