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Volume 11, Number 11—November 2005

Dispatch

West Nile Virus Epidemic, Northeast Ohio, 2002

Anna M. Mandalakas*†Comments to Author , Christopher Kippes†, Joseph Sedransk*, Jeffery R. Kile*, Asha Garg*, John McLeod†, Richard L. Berry‡, and Anthony A. Marfin§
Author affiliations: *Case Western Reserve University, Cleveland, Ohio, USA; †Cuyahoga County Board of Health, Cleveland, Ohio, USA; ‡Ohio Department of Health, Columbus, Ohio, USA; §Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Main Article

Table 2

Laboratory-based definitions used for confirmatory testing*†‡

Case Definition
Confirmed WNV infection WNV IgM MAC-ELISA positive and WNV PRNT titer >1:20 and WNV PRNT titer >2-fold than SLEV PRNT titer or
WNV PRNT titer >1:20 and WNV PRNT titer >4-fold than SLEV PRNT titer
Probable WNV infection
 WNV PRNT titer >2-fold than SLEV PRNT titer
Previous SLEV infection
 SLEV PRNT titer >1:20 and SLEV PRNT titer >2-fold than WNV PRNT titer
Probable nonspecific flavivirus infection Negative WNV and SLEV PRNT results and
Negative WNV IgM MAC-ELISA results and
Positive WNV, SLEV, or dengue IgG EIA results and
No history of YFV or JEV vaccination
Previous infection History of YFV or JEV vaccination, WNV IgM MAC-ELISA negative, and WNV and SLEV PRNT negative

*WNV, West Nile virus; IgM, immunoglobulin M; MAC-ELISA, IgM antibody capture enzyme-linked immunosorbent assay; PRNT, plaque reduction neutralization test; SLEV, St. Louis encephalitis virus; EIA, enzyme immunoassay; YFV, Yellow fever virus; and JEV, Japanese encephalitis virus.
†All specimens referred for confirmatory testing were positive for WNV IgG during initial screening.
‡Case definitions were developed in consultation with the Centers for Disease Controla nd Prevention and the Ohio Department of Health.

Main Article

Page created: February 17, 2012
Page updated: February 17, 2012
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