Volume 11, Number 2—February 2005
Research
Human Disease from Influenza A (H5N1), Thailand, 2004
Tawee Chotpitayasunondh*, Kumnuan Ungchusak†, Wanna Hanshaoworakul†, Supamit Chunsuthiwat†, Pathom Sawanpanyalert†, Rungruen Kijphati†, Sorasak Lochindarat*, Panida Srisan*, Pongsan Suwan†, Yutthasak Osotthanakorn†, Tanakorn Anantasetagoon†, Supornchai Kanjanawasri†, Sureeporn Tanupattarachai†, Jiranun Weerakul†, Ruangsri Chaiwirattana†, Monthira Maneerattanaporn†, Rapol Poolsavatkitikool†, Kulkunya Chokephaibulkit‡, Anucha Apisarnthanarak§, and Scott F. Dowell¶
Table 2
Characteristics and clinical findings of confirmed avian influenza A (H5N1) cases in Thailand, 2004*
| Characteristics | Patient no. |
% | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ||
| Age (y), sex | 2, M | 27, F | 31, M | 46, F | 5, M | 6, M | 6, M | 6, M | 7, M | 13, M | 39, F | 58, F | 67 (M) |
| Symptoms | |||||||||||||
| Fever | + | + | + | + | + | + | + | + | + | + | + | + | 100 |
| Rhinorrhea | – | + | – | – | + | + | + | – | – | – | – | – | 33 |
| Cough | + | + | + | + | + | + | + | + | + | + | + | + | 100 |
| Sore throat | + | + | – | + | + | – | + | + | + | + | – | + | 75 |
| Myalgia | – | + | + | + | – | – | – | + | – | – | + | – | 42 |
| Dyspnea | + | + | + | + | + | + | + | + | + | + | + | + | 100 |
| Diarrhea | + | – | + | – | + | – | – | + | – | – | + | – | 42 |
| Abdominal pain | – | – | – | – | + | – | + | – | – | – | – | – | 17 |
| Conjunctivitis | – | – | – | – | – | – | – | – | – | – | – | – | 0 |
| Vomiting | – | – | – | – | – | – | – | + | – | + | + | – | 25 |
| Laboratory values | |||||||||||||
| Hematocrit (vol%) | 30 | 39 | 38 | 46 | 39 | 32 | 39 | 40 | 41 | 37 | 33 | 38 | |
| Total leukocyte count | 4,200 | 13,600 | 4,660 | 7,360 | 5,600 | 1,200 | 2,200 | 4,900 | 4,100 | 2,000 | 3,300 | 5,680 | |
| Total lymphocyte count | 2,646 | 3,400 | 513 | 2,429 | 2,296 | 624 | 638 | 1,763 | 1,435 | 580 | 660 | 454 | |
| Platelet count (x103) | 214 | 306 | 171 | 272 | 94 | 89 | 140 | 111 | 304 | 150 | 380 | 185 | |
| Treatment | |||||||||||||
| Oseltamivir | + | – | + | – | + | + | – | + | + | + | – | – | 58 |
| Corticosteroids | + | – | + | – | – | + | + | + | + | + | + | – | 67 |
| Outcome | |||||||||||||
| ARDS | – | – | + | – | + | + | + | + | + | + | + | + | 75 |
| Inotropic support | – | – | – | – | + | – | – | + | + | + | – | + | 42 |
| Peak AST (U) | 129 | 18 | 74 | NA | 70 | 790 | 175 | 280 | 120 | 34 | 394 | NA | |
| Peak ALT (U) | 57 | 23 | 41 | NA | 47 | 150 | 43 | 50 | 52 | 47 | 106 | NA | |
| Peak BUN (mg/dL) | NA | 8 | 10.7 | NA | 12 | NA | 14 | 22 | 10 | 132 | 37 | 39 | |
| Peak creatinine (mg/dL) | NA | 0.8 | 1.07 | NA | 0.7 | NA | 1.7 | 1.1 | 0.7 | 8.1 | 3.6 | 2.3 | |
| Survival (day of death) | + | + | + | + | – (13) | – (20) | – (18) | – (8) | – (29) | – (16) | – (13) | – (8) | 33 |
*M, male; f, female; +, yes, –, no, NA, not applicable; ARDS, acute respiratory distress syndrome; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen.
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