Volume 11, Number 4—April 2005
Research
Experimental Infection of Prairie Dogs with Monkeypox Virus
Shu-Yuan Xiao*, Elena Sbrana*, Douglas M. Watts*, Marina Siirin*, Amelia P.A. Travassos da Rosa*, and Robert B. Tesh*
Figure 3
Figure 3. Bronchus from animal MPX-9, which was infected intranasally. A) Cross-section of a bronchus, showing focal metaplasia and proliferation (between the arrows) of the luminal epithelium. B) Higher magnification showing the details of the metaplastic epithelium, accompanied by focal necrosis. Compare to the adjacent unaffected area, which is lined by normal ciliated columnar epithelial cells. C and D) Immunohistochemical staining of the corresponding field shows presence of viral antigen limited to the region of epithelial abnormality. A and B, hematoxylin and eosin stain; C and D, immunoperoxidase staining with vaccinia antibody. Original magnification: A and C, 4× objectives; B and D, 20× objectives.
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