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Volume 11, Number 6—June 2005
Dispatch

Erythromycin-nonsusceptible Streptococcus pneumoniae in Children, 1999–2001

M. Catherine McEllistrem*Comments to Author , Jennifer M. Adams*, Kathleen Shutt*, Laurie T. Sanza†, Richard R. Facklam‡, Cynthia G. Whitney‡, James H. Jorgensen§, and Lee H. Harrison*†
Author affiliations: *University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA; †Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA; §University of Texas Health Science Center, San Antonio, Texas, USA

Main Article

Table

Annual rates of erythromycin-nonsusceptible pneumococcocal disease*

Age group Disease 1995
 1999
 2001
 1995 vs. 1999
 1999 vs. 2001
No. of cases Rate No. of cases Rate No. of cases Rate Change in rate (%) p value Change in rate (%) p value
All All invasive 683 28.1 762 31.1 599 23.6 10.7 0.05 -24.1 <0.01
Erythromycin-nonsusceptible S. pneumoniae 26 1.4 71 3.2 77 3.2 125.3 <0.01 -0.7 1.0
mefE 12 0.7 51 2.3 65 2.7 250.7 <0.01 16.7 0.4
England14-9, mefE 5 0.3 19 0.9 23 1.0 213.6 0.01 10.8 0.8
<5 y All invasive 135 76.7 146 89.3 63 38.1 16.4 0.2 -57.4 <0.01
Erythromycin-nonsusceptible S. pneumoniae 8 6.1 23 15.6 11 7.2 153.5 0.01 -53.6 0.03
mefE 3 2.3 18 12.2 9 5.9 429 <0.01 -51.5 0.07
England14-9, mefE 1 0.8 11 7.4 4 2.6 870 <0.01 -64.7 0.05
≥5 y All invasive 548 24.3 616 26.9 536 22.6 10.8 0.08 -16.1 <0.01
Erythromycin-nonsusceptible S. pneumoniae 18 1.1 48 2.3 66 2.9 119 <0.01 25.2 0.2
mefE 9 0.5 33 1.6 56 2.5 201.2 <0.01 54.6 0.04
England14-9, mefE 4 0.2 8 0.4 19 0.8 64.3 0.4 116.3 0.06

*Rate calculations: For cases where an isolate was not available, erythromycin susceptibility, presence of mefE gene, and serotype were assumed to be similar to those for which an isolate was available. For each disease category, rates >2 for ≥1 year in any age group are included in the table.

Main Article

Page created: April 24, 2012
Page updated: April 24, 2012
Page reviewed: April 24, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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