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Volume 11, Number 9—September 2005
Research

Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin

Maria Sjölund*†, Eva Tano*, Martin J. Blaser‡, Dan I. Andersson†, and Lars Engstrand*†Comments to Author 
Author affiliations: *University Hospital, Uppsala, Sweden; †The Swedish Institute for Infectious Disease Control, Solna, Sweden; ‡New York University School of Medicine, New York, New York, USA

Main Article

Table 1

Characteristics of Staphylococcus epidermidis isolated from patients*†

Patient Pretreatment‡
 Posttreatment‡
 1 year posttreatment‡
 4 years posttreatment‡
Isolate MIC DNA Isolate MIC DNA Isolate MIC DNA Isolate MIC DNA
1 1A:1 0.094 A 1B:1 0.094 F 1C:1 >256 H 1D:1 >256 H
1A:2 0.094 B 1B:2 0.094 F 1C:2 >256 H 1D:2 0.094 M
1A:3 0.125 B 1B:3 0.125 G 1C:3 32 K 1D:3 0.094 M
1A:4 0.125 B 1B:4 0.094 F 1C:4 >256 H 1D:4 0.094 B
1A:5 0.125 C 1B:5 >256 H 1C:5 >256 H 1D:5 >256 H
1A:6 0.094 B 1B:6 0.094 J 1C:6 >256 H 1D:6 0.094 C
1A:7 0.094 D 1B:7 0.094 F 1C:7 >256 H 1D:7 0.094 M
1A:8 0.094 D 1B:8 0.125 B 1C:8 >256 L 1D:8 0.094 G
1A:9 0.125 B 1B:9 >256 H 1C:9 >256 H 1D:9 >256 H
1A:10 0.064 E 1B:10 0.094 G 1C:10 >256 H 1D:10 >256 H
2 2A:1 >256 N 2B:1 >256 S 2C:1 >256 N 2D:1 0.094 P
2A:2 0.125 O 2B:2 >256 N 2C:2 >256 N 2D:2 0.094 T
2A:3 0.125 O 2B:3 >256 N 2C:3 >256 N 2D:3 >256 N
2A:4 >256 N 2B:4 >256 S 2C:4 >256 N 2D:4 >256 N
2A:5 0.125 O 2B:5 >256 S 2C:5 >256 N 2D:5 0.125 O
2A:6 0.094 P 2B:6 >256 N 2C:6 0.094 T 2D:6 0.125 P
2A:7 0.19 Q 2B:7 96 S 2C:7 0.125 T 2D:7 0.094 T
2A:8 0.125 R 2B:8 0.094 T 2C:8 >256 N 2D:8 0.125 P
2A:9 0.094 P 2B:9 >256 N 2C:9 >256 N 2D:9 >256 N
2A:10 0.094 P 2B:10 >256 S 2C:10 >256 N 2D:10 0.094 P
3 3A:1 0.125 3B:1 32 3C:1 0.125 3D:1 0.125
3A:2 0.125 3B:2 32 3C:2 >256 3D:2 >256
3A:3 0.125 3B:3 24 3C:3 0.25 3D:3 0.25
3A:4 0.094 3B:4 16 3C:4 >256 3D:4 >256
3A:5 0.125 3B:5 16 3C:5 >256 3D:5 >256
3A:6 0.125 3B:6 24 3C:6 0.094 3D:6 0.094
3A:7 0.125 3B:7 24 3C:7 >256 3D:7 >256
3A:8 0.125 3B:8 24 3C:8 >256 3D:8 >256
3A:9 0.125 3B:9 24 3C:9 0.125 3D:9 0.125
3A:10 0.19 3B:10 16 3C:10 0.125 3D:10 0.125
4 4A:1 0.125 4B:1 24 4C:1 0.125 4D:1 0.125
4A:2 0.094 4B:2 >256 4C:2 0.125 4D:2 0.125
4A:3 0.125 4B:3 24 4C:3 0.125 4D:3 0.125
4A:4 0.125 4B:4 >256 4C:4 0.125 4D:4 0.125
4A:5 0.125 4B:5 24 4C:5 0.125 4D:5 0.125
4A:6 0.125 4B:6 >256 4C:6 0.125 4D:6 0.125
4A:7 0.125 4B:7 24 4C:7 0.094 4D:7 0.094
4A:8 0.094 4B:8 >256 4C:8 0.094 4D:8 0.125
4A:9 0.094 4B:9 24 4C:9 0.125 4D:9 0.125
4A:10 0.125 4B:10 24 4C:10 0.125 4D:10 0.094
5 5A:1 0.125 5B:1 >256 5C:1 >256 5D:1 0.19
5A:2 0.125 5B:2 >256 5C:2 >256 5D:2 0.125
5A:3 0.125 5B:3 >256 5C:3 >256 5D:3 0.064
5A:4 0.125 5B:4 >256 5C:4 >256 5D:4 0.094
5A:5 0.125 5B:5 >256 5C:5 >256 5D:5 0.125
5A:6 0.125 5B:6 >256 5C:6 0.094 5D:6 0.125
5A:7 0.094 5B:7 >256 5C:7 0.125 5D:7 0.125
5A:8 0.125 5B:8 >256 5C:8 >256 5D:8 0.094
5A:9 0.125 5B:9 >256 5C:9 >256 5D:9 0.094
5A:10 0.094 5B:10 >256 5C:10 >256 5D:10 0.094

*Isolates from only 2 patients were DNA fingerprinted.
†For each patient and time point, 10 independent isolations of S. epidermidis were performed.
‡Clarithromycin MIC measured by Etest. DNA fingerprinting by pulsed-field gel electrophoresis; different patterns are indicated as letters.

Main Article

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