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Volume 12, Number 10—October 2006


ICD-9 Codes and Surveillance for Clostridium difficile–associated Disease

Erik R. Dubberke*Comments to Author , Kimberly Reske*, L. Clifford McDonald†, and Victoria Fraser*‡
Author affiliations: *Washington University in St. Louis–School of Medicine, Saint Louis, Missouri, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Barnes-Jewish Hospital, Saint Louis, Missouri, USA

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Table 2

Comparison of antimicrobial treatment for Clostridium difficile–associated disease among patient admissions with a positive C. difficile–toxin assay (CDTA+) and patients without a positive toxin assay but with ICD-9 code for C. difficile disease (CDTA–/ICD9+) (categories not mutually exclusive)

Treatment CDTA+, n = 662 (%) CDTA–/ICD9+, n= 239 (%) Odds ratio p value
Any treatment for CDAD 607 (92) 214 (90) 0.78 0.35
Metronidazole 591 (89) 187 (78) 0.43 <0.01
Oral vancomycin 130 (20) 75 (31) 1.87 <0.01
Oral vancomycin and metronidazole 114 (17) 48 (20) 1.21 0.32

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