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Volume 12, Number 7—July 2006
Letter

Mycobacterium tuberculosis Drug Resistance, Ghana

Ellis Owusu-Dabo*, Ohene Adjei*, Christian G. Meyer†Comments to Author , Rolf D. Horstmann†, Anthony Enimil‡, Thomas F. Kruppa§, Frank Bonsu¶, Edmund N.L. Browne*, Margaret Amanua Chinbuah#, Ivy Osei#, John Gyapong#, Christof Berberich*, Tanja Kubica**, Stefan Niemann**, and Sabine Ruesch-Gerdes**
Author affiliations: *Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; †Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany; ‡Komfo Anokye Teaching Hospital, Kumasi, Ghana; §Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; ¶National Tuberculosis Programme, Accra, Ghana; #Ministry of Health, Accra, Ghana; **National Reference Centre for Mycobacteria, Borstel, Germany

Main Article

Table

Resistance to first-line antituberculosis drugs, Ghana*

Isolates from HIV-negative patients, n (%) Isolates from HIV-positive patients, n (%)
Resistance 1,768† (85.7) 296† (14.3)
Any resistance 415 (23.4) 71 (24.0)
Monoresistance 255 (14.3) 49 (16.6)
H only 74 (4.2) 15 (5.1)
R only 12 (0.7) 4 (1.4)
S only 160 (9.0) 25 (8.4)
Z only 7 (<0.5) 5 (1.7)
T only 2 (<0.5)
E only
HR resistance (MDR) 39 (2.2) 4 (1.4)
HR 3 (<0.5) 1 (<0.5)
HRE 1 (<0.5)
HRS 11 (0.6) 2 (0.7)
HRZ 1 (<0.5)
HRES 6 (<0.5)
HREZ 1 (<0.5)
HRTS 3 (<0.5)
HRZS 4 (<0.5) 1 (<0.5)
HRETS 4 (<0.5)
HRESZ 5 (<0.5)
H + other resistance 116 (6.6) 15 (0.5)
HE 1 (<0.5)
HT 5 (<0.5)
HS 88 (5.0) 11 (3.7)
HES 1 (<0.5)
HTS 15 (0.8) 3 (1.0)
HSZ 6 (<0.5) 1 (<0.5)
HTSZ 1 (<0.5)
R + other resistance 1 (<0.5) 1 (<0.5)
RS only 1 (<0.5) 1 (<0.5)
Any drug resistance
Any H 232 (13.1) 36 (12.2)
Any R 54 (3.1) 10 (3.4)
Any S 306 (17.3) 45 (15.2)
Any Z 26 (1.5) 7 (2.4)
Any T 33 (3.0) 4 (2.2)
Any E 18 (1.0) 1 (<0.5)

*H, isoniazid; R, rifampin; S, streptomycin; Z, pyrazinamide; T, thiacetazone; E, ethambutol; MDR, multidrug-resistance.
†Resistance to T tested in only 1,108 isolates and 180 isolates from HIV-negative and HIV-positive persons, respectively.

Main Article

Page created: December 16, 2011
Page updated: December 16, 2011
Page reviewed: December 16, 2011
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