Volume 12, Number 7—July 2006
Letter
Mycobacterium tuberculosis Drug Resistance, Ghana
Ellis Owusu-Dabo*, Ohene Adjei*, Christian G. Meyer†
, Rolf D. Horstmann†, Anthony Enimil‡, Thomas F. Kruppa§, Frank Bonsu¶, Edmund N.L. Browne*, Margaret Amanua Chinbuah#, Ivy Osei#, John Gyapong#, Christof Berberich*, Tanja Kubica**, Stefan Niemann**, and Sabine Ruesch-Gerdes**
, Rolf D. Horstmann†, Anthony Enimil‡, Thomas F. Kruppa§, Frank Bonsu¶, Edmund N.L. Browne*, Margaret Amanua Chinbuah#, Ivy Osei#, John Gyapong#, Christof Berberich*, Tanja Kubica**, Stefan Niemann**, and Sabine Ruesch-Gerdes**
Table
Resistance to first-line antituberculosis drugs, Ghana*
| Isolates from HIV-negative patients, n (%) | Isolates from HIV-positive patients, n (%) | |
|---|---|---|
| Resistance | 1,768† (85.7) | 296† (14.3) |
| Any resistance | 415 (23.4) | 71 (24.0) |
| Monoresistance | 255 (14.3) | 49 (16.6) |
| H only | 74 (4.2) | 15 (5.1) |
| R only | 12 (0.7) | 4 (1.4) |
| S only | 160 (9.0) | 25 (8.4) |
| Z only | 7 (<0.5) | 5 (1.7) |
| T only | 2 (<0.5) | – |
| E only | – | – |
| HR resistance (MDR) | 39 (2.2) | 4 (1.4) |
| HR | 3 (<0.5) | 1 (<0.5) |
| HRE | 1 (<0.5) | – |
| HRS | 11 (0.6) | 2 (0.7) |
| HRZ | 1 (<0.5) | – |
| HRES | 6 (<0.5) | – |
| HREZ | 1 (<0.5) | – |
| HRTS | 3 (<0.5) | – |
| HRZS | 4 (<0.5) | 1 (<0.5) |
| HRETS | 4 (<0.5) | – |
| HRESZ | 5 (<0.5) | – |
| H + other resistance | 116 (6.6) | 15 (0.5) |
| HE | 1 (<0.5) | – |
| HT | 5 (<0.5) | – |
| HS | 88 (5.0) | 11 (3.7) |
| HES | – | 1 (<0.5) |
| HTS | 15 (0.8) | 3 (1.0) |
| HSZ | 6 (<0.5) | 1 (<0.5) |
| HTSZ | 1 (<0.5) | – |
| R + other resistance | 1 (<0.5) | 1 (<0.5) |
| RS only | 1 (<0.5) | 1 (<0.5) |
| Any drug resistance | ||
| Any H | 232 (13.1) | 36 (12.2) |
| Any R | 54 (3.1) | 10 (3.4) |
| Any S | 306 (17.3) | 45 (15.2) |
| Any Z | 26 (1.5) | 7 (2.4) |
| Any T | 33 (3.0) | 4 (2.2) |
| Any E | 18 (1.0) | 1 (<0.5) |
*H, isoniazid; R, rifampin; S, streptomycin; Z, pyrazinamide; T, thiacetazone; E, ethambutol; MDR, multidrug-resistance.
†Resistance to T tested in only 1,108 isolates and 180 isolates from HIV-negative and HIV-positive persons, respectively.
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