Volume 12, Number 8—August 2006
Research
Antibody Response to Pneumocystis jirovecii
Table 1
Demographic characteristics and baseline clinical measurements of patients with Pneumocystis pneumonia (PCP) and controls*
Characteristic | PCP (n = 80) | Controls (n = 41) | ||
---|---|---|---|---|
Demographic | ||||
Male (%) | 86 | 76 | ||
Race (%) | ||||
Caucasian | 55 | 39 | ||
African American | 29 | 39 | ||
Other | 16 | 22 | ||
Age at enrollment (y) | 41 ± 8 | 42 ± 8 | ||
Clinical | ||||
CD4 count (cells/μL)†‡ | 29 ± 3 | 73 ± 4 | ||
Plasma HIV RNA (copies/mL)†‡ | 123,130 ± 5 | 15,582 ± 24 | ||
Albumin (g/L) | 3.0 ± 0.5 | 3.1 ± 0.7 | ||
Prior PCP (%) | 24 | 33 | ||
Pneumonia severity | ||||
pO2 (mm Hg) | 65 ± 15.6 | 73 ± 29 | ||
Aa gradient (mm Hg) | 44 ± 13 | 41 ± 15 | ||
LDH (U/L)†‡ | 359 ± 2 | 257 ± 2 | ||
Mechanical ventilation (%) | 7 | 7 | ||
Serum antibody levels | ||||
MsgA† | 5.6 ± 4.8 | 3.7 ± 3.5 | ||
MsgB† | 2.9 ± 1.3 | 1.9 ± 0.9 | ||
MsgC† | 4.2 ± 4.3 | 4.3 ± 3.4 |
*Unless specified otherwise, values are mean ± standard deviation. pO2, oxygen pressure; Aa, alveolar-arterial; LDH, lactate dehydrogenase; Msg, major surface glycoprotein.
†Geometric mean ± geometric standard deviation.
‡Significant difference between patient groups for CD4+ count (p<0.01), plasma HIV RNA (p<0.001), LDH (p<0.001).