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Volume 13, Number 1—January 2007

Tickborne Relapsing Fever Diagnosis Obscured by Malaria, Togo

Annika Nordstrand*, Ignas Bunikis*, Christer Larsson*, Kodjo Tsogbe†, Tom G. Schwan‡, Mikael Nilsson§, and Sven Bergström*Comments to Author 
Author affiliations: *Umeå University, Umeå, Sweden; †Association Protestante des Oeuvres Médico-Sociales et Humanitaires du Togo, Lomé, Togo; ‡National Institutes of Health, Hamilton, Montana, USA; §The Swedish Institute for Infectious Disease Control, Solna, Sweden;

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Table 1

Primers used for cloning, PCR, and DNA sequencing

PrimerSequence (5′→3′)*Reference

*Sequences in boldface indicate restriction sites for BamH1 and XhoI.

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  1. Helmy N. Seasonal abundance of Ornithodoros (O.) savignyi and prevalence of infection with Borrelia spirochetes in Egypt.J Egypt Soc Parasitol. 2000;30:60719.PubMedGoogle Scholar
  2. Trape JF, Godeluck B, Diatta G, Rogier C, Legros F, Albergel J, The spread of tick-borne borreliosis in West Africa and its relationship to sub-Saharan drought.Am J Trop Med Hyg. 1996;54:28993.PubMedGoogle Scholar
  3. Anda P, Sanchez-Yebra W, del Mar Vitutia M, Perez Pastrana E, Rodriguez I, Miller NS, A new Borrelia species isolated from patients with relapsing fever in Spain.Lancet. 1996;348:1625. DOIPubMedGoogle Scholar
  4. Goubau PF, Munyangeyo C. Congenital relapsing fever caused by Borrelia duttoni. Apropos of a case in Rwanda.Ann Soc Belg Med Trop. 1983;63:3679.PubMedGoogle Scholar
  5. Cadavid D, Barbour AG. Neuroborreliosis during relapsing fever: review of the clinical manifestations, pathology, and treatment of infections in humans and experimental animals.Clin Infect Dis. 1998;26:15164. DOIPubMedGoogle Scholar
  6. World Health Organization. Vector control: methods for use by individuals and communities. Geneva: The Organization; 1997.
  7. Barbour AG. Antigenic variation of a relapsing fever Borrelia species.Annu Rev Microbiol. 1990;44:15571. DOIPubMedGoogle Scholar
  8. Barbour AG. Borrelia species and antigenic variation.Trends Microbiol. 1993;1:2369. DOIPubMedGoogle Scholar
  9. Meier JT, Simon MI, Barbour AG. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia.Cell. 1985;41:4039. DOIPubMedGoogle Scholar
  10. Shamaei-Tousi A, Martin P, Bergh A, Burman N, Brännström T, Bergström S. Borrelia crocidurae induces formation of microemboli.J Infect Dis. 1999;180:192938. DOIPubMedGoogle Scholar
  11. Trape JF, Duplantier JM, Bouganali H, Godeluck B, Legros F, Cornet JP, Tick-borne borreliosis in west Africa.Lancet. 1991;337:4735. DOIPubMedGoogle Scholar
  12. Lecompte Y, Trape JF. West African tick-borne relapsing fever.Ann Biol Clin (Paris). 2003;61:5418.PubMedGoogle Scholar
  13. Vial L, Diatta G, Tall A, Ba el H, Bouganali H, Durand P, et al. Incidence of tick-borne relapsing fever in west Africa: longitudinal study.Lancet. 2006;368:3743. DOIPubMedGoogle Scholar
  14. van Dam AP, van Gool T, Wetsteyn JC, Dankert J. Tick-borne relapsing fever imported from West Africa: diagnosis by quantitative buffy coat analysis and in vitro culture of Borrelia crocidurae.J Clin Microbiol. 1999;37:202730.PubMedGoogle Scholar
  15. Brahim H, Perrier-Gros-Claude JD, Postic D, Baranton G, Jambou R. Identifying relapsing fever Borrelia, Senegal.Emerg Infect Dis. 2005;11:4745.PubMedGoogle Scholar
  16. Porcella SF, Raffel SJ, Schrumpf ME, Schriefer ME, Dennis DT, Schwan TG. Serodiagnosis of louse-borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis.J Clin Microbiol. 2000;38:356171.PubMedGoogle Scholar
  17. Kisinza WN, McCall PJ, Mitani H, Talbert A, Fukunaga M. A newly identified tick-borne Borrelia species and relapsing fever in Tanzania.Lancet. 2003;362:12834. DOIPubMedGoogle Scholar
  18. Melkert PW, Stel HV. Neonatal Borrelia infections (relapsing fever): report of 5 cases and review of the literature.East Afr Med J. 1991;68:9991005.PubMedGoogle Scholar
  19. Climate information for Togo. 2005. [cited 2006 Oct 17]. Available from
  20. Colebunders R, De Serrano P, van Gompel A, Wynants H, Blot K, van den Enden E, Imported relapsing fever in European tourists.Scand J Infect Dis. 1993;25:5336. DOIPubMedGoogle Scholar
  21. Nordstrand A, Barbour AG, Bergstrom S. Borrelia pathogenesis research in the post-genomic and post-vaccine era.Curr Opin Microbiol. 2000;3:8692. DOIPubMedGoogle Scholar
  22. Nordstrand A, Shamaei-Tousi A, Ny A, Bergstrom S. Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.Infect Immun. 2001;69:58329. DOIPubMedGoogle Scholar

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