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Volume 13, Number 10—October 2007


Super-Sentinel Chickens and Detection of Low-Pathogenicity Influenza Virus

Philip I. Marcus*Comments to Author , Theodore Girshick†, Louis van der Heide*, and Margaret J. Sekellick*
Author affiliations: *University of Connecticut, Storrs, Connecticut, USA; †Charles River Specific Pathogen Free Avian Supplies, Storrs, Connecticut, USA;

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Table 2

Influenza A virus infectious particle equivalents (IPE) in tracheal swabs from sentinel chickens given water or water + interferon and infected naturally*

Day postinfection Water (IPE/mL) Water + interferon† (IPE/mL)
2 1,112 ± 1,353‡ 760 ± 632
4 1,234 ± 764 463 ± 484
10 1,325 ± 398 2,113 ± 1,834

*Each cage contained 2 overtly infected birds and 8 cage mates as sentinels. Only sentinel birds are reported. Chickens were 3 weeks old at the start.
†Recombinant chicken interferon-α in water at 2,000 U/mL (5).
‡Mean ± SD, n = 8. Qualitative real-time reverse transcriptase–PCR analysis with influenza A virus standard: IPE/mL.

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