Volume 13, Number 12—December 2007
Letter
Human Papillomavirus Vaccination Strategies
Table
Cost-effectiveness analysis of alternative human papillomavirus vaccination strategies*
Strategy | Discounted |
Incremental† |
||||
---|---|---|---|---|---|---|
Cost | QALY | Cost | QALY | ICER ($/QALY)‡ | ||
No vaccination | $72,659,302 | 2,698,711 | – | – | – | |
12-y-old girls | $74,042,990 | 2,699,178 | $1,383.688 | 467 | Dominated | |
18-y-old women + 18–24-y-old female catch-up | $73,553,847 | 2,699,192 | $894,545 | 481 | $1,860 | |
15-y-old girls + 15–24-y-old female catch-up | $73,895,046 | 2,699,214 | $341,199 | 22 | $15,509 | |
12-y-old girls and boys | $78,707,825 | 2,699,327 | $4,812,779 | 113 | Dominated | |
12-y-old girls + 12–24-y-old female catch-up | $74,815,667 | 2,699,343 | $920,621 | 129 | $7,137 | |
18-y-old women and men + 18–24-y-old female and male catch-up | $77,535,383 | 2,699,385 | $2,719,716 | 42 | $64,755 | |
15-y-old girls and boys + 15–24-y-old female and male catch-up | $78,455,750 | 2,699,404 | $920,367 | 19 | $48,440 | |
12-y-old girls and boys + 12–24-y-old female catch-up | $79,746,357 | 2,699,461 | $1,290,607 | 57 | $22,642 | |
12-y-old girls and boys + 12–24-y-old female and male catch-up | $81,761,210 | 2,699,506 | $2,014,853 | 45 | $44,775 |
*QALY, quality-adjusted life year; ICER, incremental cost-effectiveness ratio; $, US dollars.
†Based on discounted costs reported by Elbasha et al. (1).
‡Compared with the preceding nondominated strategy. Strategy A is dominated if there exists another strategy, B, that is more effective and less costly than strategy A.
References
- Elbasha EH, Dasbach EJ, Insinga RP. Model for assessing human papillomavirus vaccination strategies. Emerg Infect Dis. 2007;13:28–41. DOIPubMedGoogle Scholar
- Clifford GM, Gallus S, Herrero R, Munoz N, Snijders PJF, Vaccarella S, Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet. 2005;366:991–8. DOIPubMedGoogle Scholar
- HBV vaccination programmes in adolescent population 1996–1997 period [in Spanish]. Boletín Epidemiológico Semanal Instituto de Salud Carlos III. 1998;6:209–10.