Volume 13, Number 3—March 2007
Letter
gyrA Mutations in Fluoroquinolone-resistant Clostridium difficile PCR-027
Denise Drudy*
, Lorraine Kyne†, Rebecca O’Mahony*, and Séamus Fanning*
, Lorraine Kyne†, Rebecca O’Mahony*, and Séamus Fanning*
Table
Characterization of representative isolates, Ireland, 2006
| Isolate | Toxigenic status | Ribotype | Fluoroquinolone MIC μg/mL |
Amino acid substitution | ||||
|---|---|---|---|---|---|---|---|---|
| Ciprofloxacin | Ofloxacin | Levofloxacin | Gatifloxacin | Moxifloxacin | ||||
| 1470* | A-B+ | 017 | >32 | >32 | 3 | 0.38 | 0.25 | Thr 82 |
| VPI10463* | A+B+ | D | >32 | >32 | 3 | 0.38 | 0.25 | Thr 82 |
| CD 196* | A+B+ | 027 | >32 | >32 | 3 | 0.38 | 0.25 | Thr 82 |
| M216† | A+B+ | 027 | >32 | >32 | >32 | >32 | >32 | Thr-82-Iso |
| C2191† | A+B+ | 027 | >32 | >32 | >32 | >32 | >32 | Thr-82-Iso |
| V6-13† | A+B+ | 027 | >32 | >32 | >32 | >32 | >32 | Thr-82-Iso |
| V6-15† | A+B+ | 027 | >32 | >32 | >32 | >32 | >32 | Thr-82-Iso |
| V6-20† | A+B+ | 027 | >32 | >32 | >32 | >32 | >3 | Thr-82-Iso |
*Control isolates VPI-10463, 1470 CD196.
†Clinical 027 isolates from 3 different institutions investigated in this study.
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