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Volume 13, Number 5—May 2007
Letter

Expanded-spectrum β-Lactamase and Plasmid-mediated Quinolone Resistance

Laurent Poirel*Comments to Author , Laura Villa†, Alessia Bertini†, Johann D. Pitout‡, Patrice Nordmann*, and Alessandra Carattoli†
Author affiliations: *Hôpital de Bicêtre, K.-Bicêtre, France; †University of Calgary, Calgary, Alberta, Canada; ‡Istituto Superiore di Sanita, Rome, Italy;

Main Article

Table

Features of the VEB-1– or QnrA-positive isolates used in this study*

Strain†/Ref. Spp. of origin Country Year of isolation Plasmid size (kb) ESBL QnrA1 Replicon Associated non–β-lactam resistance markers
Escherichia coli TcE1 (5)
E. coli
Thailand
1999
160
VEB-1
+
A/C2
NAL, K, SSS, C, RA
E. coli TcE4 (5)
E. coli
Thailand
1999
150
VEB-1
+
A/C2
NAL, K, TM, SSS, C, RA
E. coli TcE5 (5)
E. coli
Thailand
1999
150
VEB-1
+
A/C2
NAL, K, TM, SSS, SXT
E. coli TcE7 (5)
E. coli
Thailand
1999
150
VEB-1
+
A/C2
NAL, K, TM, SSS, C, RA
E. coli TcE8 (5)
E. coli
Thailand
1999
150
VEB-1
+
A/C2
NAL, K, TM, SSS, TE
E. coli TcE16 (5)
E. coli
Thailand
1999
140
VEB-1
+
A/C2
NAL, K, TM, SSS, RA
E. coli TcE18 (5)
E. coli
Thailand
1999
180
VEB-1
+
A/C2
NAL, K, SSS, C, RA
E. coli Tc(pl) (5)
E. coli
Canada
2000
180
VEB-1
+
A/C2
NAL, K, SSS, C, RA
E. coli Tc(pQR1) (4)
E. coli
France
2003
180
VEB-1
+
A/C2
NAL, K, SSS, C, RA, SXT
E. coli Tc(GOC) (4)
Enterobacter cloacae
France
2003
190
VEB-1
+
A/C2, FIB
NAL, K, TM, SSS, C
Citrobacter freundii LUT (3)
C. freundii
Turkey
2004
ND
VEB-1
+
A/C2, FIB, K
NA
Providencia stuartii 15 (this study)
P. stuartii
Algeria
2004
ND
VEB-1

A/C2
NA
E. coli TcMAA (this study)
Proteus mirabilis
Algeria
2004
190
VEB-1

A/C2
K, TM, SSS, C, SXT
E. coli TcK147 (7)
Klebsiella pneumoniae
Australia
2002
160
SHV-12
+
HI2, A/C1, P
NAL, K, TM, C, TE, SXT
E. cloacae A1 (8)
E. cloacae
France
2004
75
SHV-12
+
HI2
NA
E. coli TcA2 (8)
Enterobacter aerogenes
France
2005
150
SHV-12
+
FII
NAL, K, TM, TE
E. coli TcA3 (8) K. pneumoniae France 2005 40 + I1, K NAL, K, TM, C, TE

*Ref., reference; ESBL, extended-spectrum β-lactamase; NAL, nalidixic acid; K, kanamycin; SSS, sulfonamides; C, chloramphenicol; RA, rifampin; TM, tobramycin; SXT, trimethoprim-sulfamethoxazole; TE, tetracycline; ND, not determinable; NA, not applicable.
†Tc indicates that this is a transconjugant or a transformant.

Main Article

References
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  6. Poirel  L, Pitout  JD, Calvo  L, Rodriguez-Martinez  JM, Church  D, Nordmann  P. In vivo selection of fluoroquinolone-resistant Escherichia coli isolates expressing plasmid-mediated quinolone resistance and expanded-spectrum β-lactamase. Antimicrob Agents Chemother. 2006;50:15257. DOIPubMed
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  9. Carattoli  A, Bertini  A, Villa  L, Falbo  V, Hopkins  KL, Threlfall  EJ. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods. 2005;63:21928. DOIPubMed
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Page updated: June 23, 2010
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