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Volume 13, Number 7—July 2007

Research

Ongoing Genome Reduction in Mycobacterium ulcerans

Simona Rondini*1, Michael Käser*1, Timothy P. Stinear†2, Michel Tessier‡, Cyrill Mangold‡, Gregor Dernick‡, Martin Naegeli*, Françoise Portaels§, Ulrich Certa‡, and Gerd Pluschke*Comments to Author 
Author affiliations: *Swiss Tropical Institute, Basel, Switzerland; †Institut Pasteur, Paris, France; ‡F. Hoffmann-La Roche Ltd., Basel, Switzerland; §Institute of Tropical Medicine, Antwerp, Belgium; 1These authors contributed equally to this work.; 2Current affiliation: Monash University, Melbourne, Victoria, Australia;

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Figure 6

Functional categories of coding sequences (CDSs) and pseudogenes and their frequencies in the deletions and the whole genome. CDSs and pseudogenes in the identified regions of difference (RDs) and in the entire reference Mycobacterium ulcerans Agy99 genome were functionally categorized; the frequencies of individual categories are compared. Statistically overrepresented in the RDs were pseudogenes; insertion sequences; CDSs encoding unique hypothetical proteins; and proteins involved in virulenc

Figure 6. Functional categories of coding sequences (CDSs) and pseudogenes and their frequencies in the deletions and the whole genome. CDSs and pseudogenes in the identified regions of difference (RDs) and in the entire reference Mycobacterium ulcerans Agy99 genome were functionally categorized; the frequencies of individual categories are compared. Statistically overrepresented in the RDs were pseudogenes; insertion sequences; CDSs encoding unique hypothetical proteins; and proteins involved in virulence, detoxification, and adaptation. *Significant differences (p<0.05).

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