Figure 6. Functional categories of coding sequences (CDSs) and pseudogenes and their frequencies in the deletions and the whole genome. CDSs and pseudogenes in the identified regions of difference (RDs) and in the entire reference Mycobacterium ulcerans Agy99 genome were functionally categorized; the frequencies of individual categories are compared. Statistically overrepresented in the RDs were pseudogenes; insertion sequences; CDSs encoding unique hypothetical proteins; and proteins involved in virulence, detoxification, and adaptation. *Significant differences (p<0.05).