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Volume 13, Number 7—July 2007
Perspective

Brazilian Vaccinia Viruses and Their Origins

Giliane S. Trindade*1, Ginny L. Emerson*1, Darin S. Carroll*, Erna G.†, and Inger K. Damon*Comments to Author 

Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;

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Table 3

Brazilian Vaccinia viruses and vaccine strains used in Brazil*

VirusYear of
isolationSourcePlace of isolation and biomeReference
VACV-LIS1870Prussian soldierVaccine Institute, Cologne, Germany (3)
VACV-WR1876NYCBH strainNew York City Department of Health Laboratory (3)
SAV†1961Rodent, sentinel miceSão Paulo State, Atlantic tropical rainforest, Brazil (6)
BAV1963Rodent, Oryzomys sp.Para State, Amazon tropical rainforest, Brazil (4,5)
VBH1998Rodent, BALB-c miceMinas Gerais State, Cerrado woodland/savanna, Brazil (9)
ARAV1999CowSão Paulo State, Cerrado woodland/savanna Brazil (7)
CTGV1999CowRio de Janeiro State, Atlantic tropical rainforest, Brazil (8)
GP1V2001CowMinas Gerais State, Atlantic tropical rainforest, Brazil (13)
GP2V2001CowMinas Gerais State, Atlantic tropical rainforest (13)
PSTV2003CowMinas Gerais State, Atlantic tropical rainforest, Brazil (11)
VACV-IOCND†Probable Paris strainND (3,8)

* VACV, vaccinia virus; LIS, Lister; WR, Western Reserve; NYCBH, New York City Board of Health; SAV, SpAn232 virus; BAV, BeAn 58058 virus; VBH, Belo Horizonte virus; ARAV, Araçatuba virus; CTGV, Cantagalo virus; GP, Guarani virus; PSTV, Passatempo virus; IOC, Oswaldo Cruz Institute; ND, not determined.
†This virus was studied by the viral laboratory in Minas Gerais State in 1979 and cloned in Vero cells during the 1990s (4). It was originally collected and referred to as Cotia virus, which was repeatedly isolated throughout the 1960s and 1970s by the Adolfo Lutz Institute in Brazil (33).

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References
  1. Lewis-Jones S. Zoonotic poxvirus infections in humans.Curr Opin Infect Dis. 2004;17:81–9. DOIPubMedGoogle Scholar
  2. Fernandes T. The smallpox vaccine: its first century in Brazil (from the Jennerian to the animal vaccine)[in Spanish]. Hist Cienc Saude Manguinhos. 1999;6:29–51. DOIPubMedGoogle Scholar
  3. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and its eradication. Geneva: World Health Organization; 1988.
  4. Fonseca FG, Lanna MC, Campos MAS, Kitajima EW, Peres JN, Golgher RR, Morphological and molecular characterization of the poxvirus BeAn 58058.Arch Virol. 1998;143:1171–86. DOIPubMedGoogle Scholar
  5. Marques JT, Trindade GS, da Fonseca FG, dos Santos JR, Bonjardim CA, Ferreira PCP, Characterization of ATI, TK and IFN-alpha/betaR genes in the genome of the BeAn 58058 virus, a naturally attenuated wild orthopoxvirus.Virus Genes. 2001;23:291–301. DOIPubMedGoogle Scholar
  6. da Fonseca FG, Trindade GS, Silva RL, Bonjardim CA, Ferreira PC, Kroon EG. Characterization of a vaccinia-like virus isolated in a Brazilian forest.J Gen Virol. 2002;83:223–8.PubMedGoogle Scholar
  7. de Souza Trindade G, da Fonseca FG, Marques JT, Nogueira ML, Mendes LC, Borges AS, Araçatuba virus: a vaccinialike virus associated with infection in humans and cattle.Emerg Infect Dis. 2003;9:155–60.PubMedGoogle Scholar
  8. Damaso CR, Esposito JJ, Condit RC, Moussatche N. An emergent poxvirus from humans and cattle in Rio de Janeiro State: Cantagalo virus may derive from Brazilian smallpox vaccine.Virology. 2000;277:439–49. DOIPubMedGoogle Scholar
  9. Trindade GS, da Fonseca FG, Marques JT, Diniz S, Leite JA, De Bodt S, Belo Horizonte virus: a vaccinia-like virus lacking the A-type inclusion body gene isolated from infected mice.J Gen Virol. 2004;85:2015–21. DOIPubMedGoogle Scholar
  10. Nagasse-Sugahara TK, Kisielius JJ, Ueda-Ito M, Curti SP, Figueiredo CA, Cruz AS, Human vaccinia-like virus outbreaks in São Paulo and Goias States, Brazil: virus detection, isolation and identification.Rev Inst Med Trop Sao Paulo. 2004;46:315–22. DOIPubMedGoogle Scholar
  11. Leite JA, Drumond BP, Trindade G, Lobato ZIP, da Fonseca FG, Santos JR, Passatempo virus, a vaccinia virus strain, Brazil.Emerg Infect Dis. 2005;11:1935–8.PubMedGoogle Scholar
  12. Lobato ZIP, Trindade GS, Frois MCM, Ribeiro EBT, Dias GRC, Teixeira BM, Outbreak of exanthemal disease caused by vaccinia virus in human and cattle in Zona da Mata region, Minas Gerais[in Portuguese]. Arq Bras Med Vet Zootec.2005;57:423–9. DOIGoogle Scholar
  13. Trindade GS, Lobato ZIP, Drumond BP, Leite JA, Trigueiro RC, Guedes MIMC, Isolation of two vaccinia virus strains from a single bovine vaccinia outbreak in rural area from Brazil: implications on the emergence of zoonotic orthopoxviruses.Am J Trop Med Hyg. 2006;75:486–90.PubMedGoogle Scholar
  14. Johnson GP, Goebel SJ, Paoletti E. An update on the vaccinia virus genome.Virology. 1993;196:381–401. DOIPubMedGoogle Scholar
  15. Dumbell K, Richardson M. Virological investigations of specimens from buffaloes affected by buffalopox in Maharashtra State, India between 1985 and 1987.Arch Virol. 1993;128:257–67. DOIPubMedGoogle Scholar
  16. Kolhapure RM, Tupe CD, Deolankar RP, Raut CG, Basu A, Dama BM, Investigation of buffalopox outbreaks in Maharashtra State during 1992-1996.Indian J Med Res. 1997;106:441–6.PubMedGoogle Scholar
  17. Singh RK, Hosamani M, Balamurugan V, Satheesh CC, Rasool TJ, Yadav MP. Comparative sequence analysis of envelope protein genes of Indian buffalopox virus isolates.Arch Virol. 2006;151:1995–2005. DOIPubMedGoogle Scholar
  18. Tulman ER, Delhon G, Afonso CL, Lu Z, Zsak L, Sandybaev NT, Genome of horsepox virus.J Virol. 2006;80:9244–58. DOIPubMedGoogle Scholar
  19. Swofford DL. PAUP*. Phylogenetic Analysis Using Parsimony (*and other methods). Version 4. Sunderland (MA): Sinauer Associates; 2003.
  20. Huelsenbeck JP, Ronquist F. MRBAYES: Bayesian inference of phylogenetic trees.Bioinformatics. 2001;17:754–5. DOIPubMedGoogle Scholar
  21. Ronquist F, Huelsenbeck JP. MrBayes 3: Bayesian phylogenetic inference under mixed models.Bioinformatics. 2003;19:1572–4. DOIPubMedGoogle Scholar
  22. Posada D, Crandall KA. MODELTEST: testing the model of DNA substitution.Bioinformatics. 1998;14:817–8. DOIPubMedGoogle Scholar
  23. Posada D, Buckley TR. Model selection and model averaging in phylogenetics: advantages of Akaike information criterion and Bayesian approaches over likelihood ratio tests.Syst Biol. 2004;53:793–808. DOIPubMedGoogle Scholar
  24. Ropp SL, Jin Q, Knight JC, Massung RF, Esposito JJ. PCR strategy for identification and differentiation of smallpox and other orthopoxviruses.J Clin Microbiol. 1995;33:2069–76.PubMedGoogle Scholar
  25. Damaso CR, Reis SA, Jesus DM, Lima PS, Moussatche N. A PCR-based assay for detection of emerging vaccinia-like viruses isolated in Brazil.Diagn Microbiol Infect Dis. 2006;57:39–46. DOIPubMedGoogle Scholar
  26. Meyer H, Damon IK, Esposito JJ. Orthopoxvirus diagnostics. In: Isaacs, SN, editor. Vaccinia virus and poxvirology: methods and protocols. Totowa (NJ): Humana Press; 2004 p. 119–33.
  27. Lewis A, Bok K, Perez O, De Fillipo J, Paolazzi C, Gomes JA. Characterization of a Vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970.Arch Virol. 2005;150:1485–91. DOIPubMedGoogle Scholar
  28. World Health Organization. Archives of the Smallpox Eradication Programme. [cited 2007 May 17.] Available from http://www.who.int/archives/fonds_collections/bytitle/fonds_6/en/index.html
  29. Turner GS. Respiratory infection of mice with vaccinia virus.J Gen Virol. 1967;1:399–402. DOIPubMedGoogle Scholar
  30. Wokatsch R. Vaccinia virus. In: Majer M, Plotkin SA, editors. Strains of human viruses. Basel: S. Karger; 1972.
  31. de Souza Lopes O, Lacerda JP, Fonseca IE, Castro DP, Forattini OP, Rabello EX. Cotia virus: a new agent isolated from sentinel mice in São Paulo, Brazil.Am J Trop Med Hyg. 1965;14:156–7.PubMedGoogle Scholar
  32. Ueda Y, Dumbell KR, Tsuruhara T, Tagaya I. Studies on Cotia virus—an unclassified poxvirus.J Gen Virol. 1978;40:263–76. DOIPubMedGoogle Scholar
  33. Ueda Y, Morikawa S, Watanabe T. Unclassified poxvirus: characterization and physical mapping of Cotia virus DNA and location of a sequence capable of encoding a thymidine kinase.Virology. 1995;210:67–72. DOIPubMedGoogle Scholar
  34. Esposito JJ, Palmer EL, Borden EC, Harrison AK, Obijeski JF, Murphy FA. Studies on the poxvirus Cotia.J Gen Virol. 1980;47:37–46. DOIPubMedGoogle Scholar
  35. Conservational International [cited 2006 Sep 2]. Available from http://www.biodiversityhotspots.org/xp/Hotspots/atlantic_forest
  36. Benchimol JL. Febre Amarela: a doença e a vacina, uma historia inacabada. Rio de Janeiro: Editora Fiocruz; 2001.

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1These authors contributed equally to this work.

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Page updated: June 23, 2010
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