Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 14, Number 12—December 2008
Research

Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Red Foxes Fed Infected Bird Carcasses

Leslie A. Reperant, Geert van Amerongen, Marco W.G. van de Bildt, Guus F. Rimmelzwaan, Andrew P. Dobson, Albert D.M.E. Osterhaus, and Thijs KuikenComments to Author 
Author affiliations: Princeton University, Princeton, New Jersey, USA (L.A. Reperant, A.P. Dobson); Erasmus Medical Centre, Rotterdam, the Netherlands (G. van Amerongen, M.W.G. van de Bildt, G.F. Rimmelzwaan, A.D.M.E. Osterhaus, T. Kuiken)

Main Article

Figure 2

Lesions and associated expression of influenza virus antigen in respiratory and extrarespiratory organs of foxes infected intratracheally with HPAI virus (H5N1), at 7 days postinoculation. A) Lungs of control fox sham-inoculated with phosphate-buffered saline. B) Lungs of intratracheally inoculated fox presenting extensive consolidated lesions (darkened areas), characterized by C) diffuse alveolar damage and regeneration (type II pneumocyte hyperplasia) and D) expression of influenza virus antig

Figure 2. Lesions and associated expression of influenza virus antigen in respiratory and extrarespiratory organs of foxes infected intratracheally with HPAI virus (H5N1), at 7 days postinoculation. A) Lungs of control fox sham-inoculated with phosphate-buffered saline. B) Lungs of intratracheally inoculated fox presenting extensive consolidated lesions (darkened areas), characterized by C) diffuse alveolar damage and regeneration (type II pneumocyte hyperplasia) and D) expression of influenza virus antigen in the nucleus and, to a lesser extent, cytoplasm of mononuclear and epithelial cells. E) Focus of inflammation and cardiomyocytic necrosis in the heart, associated with F) expression of influenza virus antigen in the nucleus of cardiomyocytes. G) Focus of gliosis and neuronal necrosis in the cerebrum, associated with H) expression of influenza virus antigen in the nucleus and, to a lesser extent, cytoplasm of glial cells and neurons. Panels C–H, original magnification ×40.

Main Article

Page created: July 22, 2010
Page updated: July 22, 2010
Page reviewed: July 22, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external