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Volume 14, Number 7—July 2008
Online Report
Peer Reviewed Report Available Online Only

Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei

Sharon J. Peacock*Comments to Author , Herbert P. Schweizer†, David A.B. Dance‡, Theresa L. Smith§, Jay E. Gee§, Vanaporn Wuthiekanun*, David DeShazer¶, Ivo Steinmetz#, Patrick Tan, and Bart J. Currie††
Author affiliations: *Mahidol University, Bangkok, Thailand; †Colorado State University, Fort Collins, Colorado, USA; ‡Health Protection Agency (South West), Plymouth, UK; §Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ¶US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA; #Universität Greifswald, Greifswald, Germany; **Genome Institute of Singapore, Singapore; ††Menzies School of Health Research and Royal Darwin Hospital, Darwin, Northern Territory, Australia;

Main Article

Table 2

Recommended Burkholderia pseudomallei postexposure antimicrobial drug prophylaxis

Antimicrobial drug Dosage Frequency
Trimethoprim-sulfamethoxazole (TMP-SMX) 2 × 160–800 mg (960 mg) tablets if >60 kg, 3 × 80–400 (480 mg) tablets if 40 kg-60 kg, and 1 × 160–800 mg (960 mg) or 2 × 80–400 (480 mg) tablets if adult <40 kg plus
folate 5 mg/d Every 12 h
Doxycycline 2.5 mg/kg/dose up to 100 mg orally Every 12 h
Amoxicillin–clavulanic acid 20/5 mg/kg/dose. Equates to 3 × 500/125 tabs if >60 kg, and 2 × 500/125 tabs if <60kg Every 8 h

Main Article

Page created: July 12, 2010
Page updated: July 12, 2010
Page reviewed: July 12, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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