Volume 14, Number 7—July 2008
Peer Reviewed Report Available Online Only
Management of Accidental Laboratory Exposure to Burkholderia pseudomallei and B. mallei
|Initial parenteral therapy|
|Ceftazidime 50 mg/kg/dose (up to 2 g) every 6–8 h,* or meropenem 25 mg/kg/dose (up to 1 g) every 8 h*|
|Duration of therapy a minimum of 10–14 d, and longer (4–8 wk) for deep-seated infection
|Oral eradication therapy|
|Trimethoprim-sulfamethoxazole orally every 12 h 2 × 160–800 mg (960 mg) tablets if >60 kg, 3 × 80–400 (480 mg) tablets if 40–60 kg, and 1 × 160–800 mg (960 mg) or 2 × 80–400 (480 mg) tablets if adult <40 kg; ± doxycycline 2.5 mg/kg/dose up to 100 mg orally every 12 h plus folate 5 mg/d Duration at least 3–6 mo|
*Plus trimethoprim-sulfamethoxazole 8/40 mg/kg (up to 320/1,600 mg) every 12 h for treatment of patients with neurologic, prostatic, bone, or joint melioidosis.
Page created: July 12, 2010
Page updated: July 12, 2010
Page reviewed: July 12, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.