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Volume 15, Number 10—October 2009

Nontuberculous Mycobacteria Infections and Anti–Tumor Necrosis Factor-α Therapy

Kevin L. WinthropComments to Author , Eric Chang, Shellie Yamashita, Michael F. Iademarco, and Philip A. LoBue
Author affiliations: Oregon Health and Sciences University, Portland, Oregon, USA (K.L. Winthrop, E. Chang, S. Yamashita); US Public Health Service, Washington, DC, USA (M.F. Iademarco); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (P.A. LoBue)

Main Article

Table 1

Reported diseases associated with anti–TNF-α therapy and therapy implicated for 105 cases of NTM disease, US Food and Drug Administration MedWatch database, 1999–2006*

Disease Infliximab Etanercept Adalimumab
Rheumatoid arthritis (n = 73) 51 17 5
Ankylosing spondylitis (n = 5) 1 3 1
Psoriasis (n = 4) 2 2 0
Crohn disease (n = 8) 8 0 0
Other (n = 15)† 11 3 1

*TNF-α, tumor necrosis factor-α; NTM, nontuberculous mycobacteria.
†Includes Wegener granulomatosis (n = 2), dermatomyositis (n = 1), uveitis (n = 1), juvenile rheumatoid arthritis (n = 1), and not reported (n = 10).

Main Article

Page created: December 08, 2010
Page updated: December 08, 2010
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.