Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 15, Number 11—November 2009
Letter

Preexisting Immunity to Pandemic (H1N1) 2009

Zheng XingComments to Author  and Carol J. Cardona
Author affiliations: University of California, Davis, CA, USA (Z. Xing, C.J. Cardona); Medical School, Nanjing University, Nanjing, People’s Republic of China (Z. Xing)

Main Article

Table

Conserved MHC class I antigen-restricted epitopes present in HA and NP proteins of pandemic (H1N1) 2009 virus*

MHC antigen
Epitope
position
Sequence
Identified in selected
virus isolates
HA
HLA-A*0201 344–353 GLFGAIAGFI A/New Caledonia/20/1999 (H1N1)
A/Solomon Islands/3/2006 (H1N1)
A/Macau/229/2008 (H1N1)
A/Managua/254.01/2008(H1N1
NP
HLA-A1 44–52 CTELKLSDY A/Hong Kong/HKU4/2004 (H3N2)
HLA-A*0101 A/Canterbury/200/2004 (H3N2)
HLA-A3 265–273 ILRGSVAHK A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/Managua/254.01/2008(H1N1)
A/Taiwan/2645/2006 (H1N1)
HLA-B27 380–393 ELRSRYWAIRTRSG A/New Caledonia/20/1999 (H1N1)
A/Taiwan/2645/2006 (H1N1)
A/Managua/254.01/2008(H1N1)
A/Florida/UR06-0383/2007(H1N1)
HLA-B27 174–184 RRSGAAGAAVK A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/California/UR07-0067/2008 (H3N2)
A/Taiwan/2645/2006 (H1N1)
HLA-B*2705 357–370 KLSTRGVQIASNEN A/New Caledonia/20/1999 (H1N1)
A/New York/55/2004 (H3N2)
A/Hong Kong/HKU77/2005 (H3N2)
A/Managua/3153.01/2008 (H1N1)
HLA-B*2705 383–391 SRYWAIRTR A/New Caledonia/20/1999
A/Taiwan/2645/2006 (H1N1)
A/Managua/4537.03/2008 (H1N1)
A/Florida/UR07-0026/2008 (H1N1)
HLA-B*2702 381–388 LRSRYWAI A/New Caledonia/20/1999
A/Florida/UR06-0383/2007(H1N1)
HLA-B*4002 251–259 AEIEDLIFL A/Canterbury/200/2004 (H3N2)
A/Hong Kong/HKU71/2005 (H3N2)
HLA-B8 225–233 ILKGKFQTA A/New Caledonia/20/1999
A/California/UR07-0067/2008 (H3N2)
A/Taiwan/2645/2006 (H1N1)
HLA-B8 380–388 ELRSRYWAI A/New Caledonia/20/1999 (H1N1)
HLA-B*0801 A/Taiwan/2645/2006 (H1N1)
A/Managua/107.01/2008 (H1N1)
A/Florida/UR07-0026/2008 (H1N1)

*HA, hemagglutinin; NP, nucleoprotein; MHC, major histocompatibility complex; NA, neuraminidase. Epitope binding to and/or activation of specific lymphocytes prepared from human peripheral blood mononuclear cells (PBMC): MHC-tetramer staining; T-cell receptor binding; ELISPOT and intracellular cytokine staining (interferon γ), and/or 51Chromine release and killing have been demonstrated in published studies. Data on epitope characterization were collected from the Immune Epitope Database (IEDB; www.immuneepitope.org) (4).

Main Article

References
  1. Centers for Disease Control and Prevention. Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep. 2009;58:5214.PubMed
  2. Centers for Disease Control and Prevention. Update: infections with a swine-origin influenza A (H1N1) virus—United States and other countries, April 28, 2009. MMWR Morb Mortal Wkly Rep. 2009;58:4313.PubMed
  3. Garten  RJ, Davis  CT, Russell  CA, Shu  B, Lindstrom  S, Balish  A, Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009;325:197201. DOIPubMed
  4. Peters  B, Sidney  J, Bourne  P, Bui  HH, Buus  S, Doh  G, The immune epitope database and analysis resource: from vision to blueprint. PLoS Biol. 2005;3:e91. DOIPubMed
  5. Kwok  WW, Yang  J, James  E, Bui  J, Huston  L, Roti  M. Identification of 13mer epitopes for DRB1*0101, DRB1*0401, DRB1*0404, and DRB1*0701 restricted CD4+ T cell epitopes for tetanus toxoid and several influenza proteins 2009 [cited 2009 Sep 2]. Available from http://immuneepitope.org/refId/1013360
  6. Kosor Krnic  E, Gagro  A, Drazenovic  V, Kuzman  I, Jeren  T, Cecuk-Jelicic  E, Enumeration of haemagglutinin-specific CD8+ T cells after influenza vaccination using MHC class I peptide tetramers. Scand J Immunol. 2008;67:8694.PubMed
  7. Couch  RB. Seasonal inactivated influenza virus vaccines. Vaccine. 2008;26(Suppl 4):D59. DOIPubMed
  8. Boon  AC, de Mutsert  G, van Baarle  D, Smith  DJ, Lapedes  AS, Fouchier  RA, Recognition of homo- and heterosubtypic variants of influenza A viruses by human CD8+ T lymphocytes. J Immunol. 2004;172:245360.PubMed
  9. McElhaney  JE, Xie  D, Hager  WD, Barry  MB, Wang  Y, Kleppinger  A, T cell responses are better correlates of vaccine protection in the elderly. J Immunol. 2006;176:63339.PubMed
  10. McMichael  AJ, Gotch  FM, Noble  GR, Beare  PA. Cytotoxic T-cell immunity to influenza. N Engl J Med. 1983;309:137.PubMed

Main Article

Page created: December 09, 2010
Page updated: December 09, 2010
Page reviewed: December 09, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external