Volume 15, Number 12—December 2009
Research
Genomic Signatures of Influenza A Pandemic (H1N1) 2009 Virus
Guang-Wu Chen
and Shin-Ru Shih
and Shin-Ru Shih
Table 2
Amino acid residues of pandemic (H1N1) 2009 virus strains at 8 positions where swine–human signatures are located*
| Gene | Position | Swine virus residue (all subtypes) | Human virus residue | Pandemic (H1N1) 2009 virus residue |
|---|---|---|---|---|
| PB2 |
44 |
A(301), S(27), C(1) |
S(2,734), A(30), L(2) |
A(61) |
| PA | 268 | L(325), I(31), T(1) | I(2,724), L(35), V(2) | L(61) |
| 552 |
T(280), S(25) |
S(2,721), T(10), N(2), I(1), R(1) |
T(61) |
|
| M1 |
137 |
T(429), A(39) |
A(3,577), T(25) |
T(146) |
| M2 | 57 | Y(343), H(23), R(2) | H(3,804),Y(65), D(25), Q(5), R(5), N(4) | Y(55) |
| 86 | V(324), A(24), S(1) | A(3,781), V(26), T(10), D(1) | V(55) | |
| 93 |
N(320), S(23) |
S(3,699), N(69), Q(2), R(1), H(1), I(1) |
N(55) |
|
| NS2 | 107 | L(299), F(25) | F(2,850), L(45), S(1), V(1) | L(93) |
*Boldface indicates dominant amino acid residue type. PB, polymerase B; PA, polymerase A; M, matrix; NS, nonstructural.
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